A New Dammarane-Type Saponin from the Rhizomes of Panax japonicus
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DOI: 10.1007/s10600-018-2452-6
Abstract: A new dammarane-type saponin, named yesanchinoside R3 (1), along with three known compounds, has been isolated from the rhizomes of Panax japonicus. Their structures were elucidated on the basis of spectroscopic evidence. read more here.
Keywords: type saponin; rhizomes panax; dammarane type; new dammarane ... See more keywords
New perspective on the metabolism of AD-1 in vivo: Characterization of a series of dammarane-type derivatives with novel metabolic sites and anticancer mechanisms of active oleanane-type metabolites.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.102961
Abstract: 20(R)-25-methoxyl-dammarane-3β,12β,20-triol (AD-1, CN Patent: 201010107476.7) is a novel derivative of dammarane-type ginsenoside. AD-1 has been shown to inhibit cancer cell proliferation without significant host toxicity in vivo, and has excellent development potential as a new… read more here.
Keywords: dammarane; metabolism; dammarane type; cancer ... See more keywords
New dammarane-type glycosides from Gynostemma pentaphyllum and their lipid-lowering activity.
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DOI: 10.1016/j.bioorg.2021.104843
Abstract: Gynostemma pentaphyllum (Thunb.) Makino has a long history as food and diary supplement in China. At present, there are some products for hyperlipidemia in the market, including G. pentaphyllum tea, healthy wine and healthy food.… read more here.
Keywords: type glycosides; dammarane type; gynostemma pentaphyllum; pentaphyllum ... See more keywords
New dammarane-type triterpenoid saponins from Panax notoginseng saponins
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DOI: 10.1016/j.jgr.2018.12.001
Abstract: Background Panax notoginseng saponin (PNS) is the extraction from the roots and rhizomes of Panaxnotoginseng (Burk.) F. H. Chen. PNS is the main bioactive component of Xuesaitong, Xueshuantong, and other Chinese patent medicines, which are… read more here.
Keywords: triterpenoid saponins; panax notoginseng; dammarane type; new dammarane ... See more keywords
Dammarane-type saponins from the leaves of Panax notoginseng and their neuroprotective effects on damaged SH-SY5Y cells.
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DOI: 10.1016/j.phytochem.2017.09.020
Abstract: Seven dammarane-type saponins previously undescribed (notoginsenosides Fh1-Fh7) were isolated from the aqueous extract leaves of Panax notoginseng (Burk.) F.H.Chen (Araliaceae), together with eleven known saponins. Their structures of were elucidated by spectroscopic analysis (NMR, UV,… read more here.
Keywords: leaves panax; neuroprotective effects; panax notoginseng; dammarane type ... See more keywords
Dammarane-Type Triterpenoids from the Roots of Rhus chinensis and Their Preventive Effects on Zebrafish Heart Failure and Thrombosis.
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DOI: 10.1021/acs.jnatprod.9b00857
Abstract: Eight new dammarane-type triterpenoids (1-8), together with a related known analogue (9), were isolated from the roots of Rhus chinensis, a traditional Chinese medicine for treating coronary artery heart disease, guided by LC-MS analysis. Their… read more here.
Keywords: type triterpenoids; heart; dammarane type; heart failure ... See more keywords
Two new dammarane-type ginsenosides from Panax ginseng.
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DOI: 10.1080/14786419.2021.1991338
Abstract: Two new dammarane-type ginsenosides elucidated as 3-O-[β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl]-20-O-[α-D-glucopyranosyl-(1→4)-β-D-glucopyranosyl]-20(S)-protopanaxadiol, named Ginsenoside Rb6(2); (Z)-6-O-β-D-glucopyranosyl-dammar-20(22), 24-diene-3β, 6α, 12β-triol, named (20Z)-Ginsenoside Rh4 (4); along with five known ginsenosides(1, 3, 5, 6, 7) were isolated from the radix and rhizome of… read more here.
Keywords: dammarane type; glucopyranosyl; glucopyranosyl glucopyranosyl; type ginsenosides ... See more keywords
Two new dammarane-type saponins from radix and rhizomes of Panax ginseng C. A. Meyer.
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DOI: 10.1080/14786419.2022.2150848
Abstract: Two new dammarane-type ginsenosides elucidated as 6-O-[α-D-glucopyranosyl-(1→3)-β-D-glucopyranosyl]-dammar-24-ene-3β, 6α, 12β, 20S-tetraol, named 20(S)-Ginsenoside Re10 (4); 6-O-[α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranosyl]-20-O-[α-D-glucopyranosyl-(1→4)-β-D-glucopyranosyl]-dammar-24-ene-3β, 6α, 12β, 20R-tetraol, named 20(R)-Ginsenoside Re11 (8); along with one steroidal saponin (1) and six known triterpenoid ginsenosides (2, 3,… read more here.
Keywords: radix rhizomes; dammarane type; new dammarane; panax ginseng ... See more keywords
Antineoplastic Activity, Structural Modification, Synthesis and Structure-activity Relationship of Dammarane-type Ginsenosides: An Overview
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DOI: 10.2174/1385272823666190401141138
Abstract: Dammarane-type ginsenosides are a class of tetracyclic triterpenoids with the same dammarane skeleton. These compounds have a wide range of pharmaceutical applications for neoplasms, diabetes mellitus and other metabolic syndromes, hyperlipidemia, cardiovascular and cerebrovascular diseases,… read more here.
Keywords: structural modification; dammarane type; disease; activity ... See more keywords
New Dammarane-Type Triterpenoid Saponins from Panax notoginseng Leaves and Their Nitric Oxide Inhibitory Activities
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DOI: 10.3390/molecules25010139
Abstract: Inflammation is a very common and important pathological process that can cause many diseases. The discovery of anti-inflammatory drugs and the treatment of inflammation are particularly essential. Dammarane-type triterpenoid saponins (PNS) were demonstrated to show… read more here.
Keywords: dammarane; triterpenoid saponins; inhibitory activities; dammarane type ... See more keywords
Dammarane-Type Triterpenoid from the Stem Bark of Aglaia elliptica (Meliaceae) and Its Cytotoxic Activities
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DOI: 10.3390/molecules27196757
Abstract: Two new dammarane-type triterpenoid fatty acid ester derivatives, 3β-oleate-20S-hydroxydammar-24-en (1) and 3β-oleate-20S,24S-epoxy-25-hydroxydammarane (2) with a known dammarane-type triterpenoid compound, such as 20S-hydroxydammar-24-en-3-on (3), were isolated from the stem bark of Aglaia elliptica (C.DC.) Blume. The… read more here.
Keywords: bark aglaia; stem bark; type triterpenoid; dammarane type ... See more keywords