Ruxolitinib combined with prednisone, thalidomide and danazol in patients with myelofibrosis: Results of a pilot study
Sign Up to like & getrecommendations! Published in 2022 at "Hematological Oncology"
DOI: 10.1002/hon.3026
Abstract: Ruxolitinib is a safe and effective therapy of myeloproliferative neoplasm‐associated (MPN) myelofibrosis. However, often there are dose reductions and/or therapy interruptions because of therapy‐related adverse events (AEs), especially anemia and thrombocytopenia. We previously reported combined… read more here.
Keywords: ruxolitinib; study group; danazol; group ... See more keywords
Danazol alters mitochondria metabolism of fibrocystic breast Mcf10A cells.
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DOI: 10.1016/j.breast.2017.06.007
Abstract: Fibrocystic Breast Disease (FBD) or Fibrocystic change (FC) affects about 60% of women at some time during their life. Although usually benign, it is often associated with pain and tenderness (mastalgia). The synthetic steroid danazol… read more here.
Keywords: mcf10a cells; breast; energy; metabolism ... See more keywords
Thalidomide plus prednisone with or without danazol therapy in myelofibrosis: a retrospective analysis of incidence and durability of anemia response
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DOI: 10.1038/s41408-017-0029-4
Abstract: Low-dose thalidomide and prednisone alone or combined are effective therapies in some persons with primary myelofibrosis (PMF) and anemia with or with RBC transfusion dependence. Danazol is also effective in some persons with PMF and… read more here.
Keywords: prednisone; thalidomide prednisone; pmf anemia; response ... See more keywords
Danazol increases T regulatory cells in patients with aplastic anemia
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DOI: 10.1080/10245332.2018.1435045
Abstract: ABSTRACT Objectives: Danazol is an attenuated androgen and is used in the treatment of aplastic anemia (AA) in resource constraint settings. We chose to study the role of CD4+ CD25high CD127low FoxP3+ T regulatory cells… read more here.
Keywords: regs; aplastic anemia; treatment; regulatory cells ... See more keywords