Exogenous nanoparticles and endogenous crystalline molecules as danger signals for the NLRP3 inflammasomes
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27475
Abstract: Inflammasome mechanisms are involved as some of the pathways of sterile inflammation. Inflammasomes are large multiprotein complexes in the cytosol and are a key system for the production of the pivotal inflammatory cytokines, interleukin (IL)‐1β… read more here.
Keywords: danger signals; nlrp3 inflammasomes; inflammation; endogenous crystalline ... See more keywords
HDAC7 is an immunometabolic switch triaging danger signals for engagement of antimicrobial versus inflammatory responses in macrophages.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2212813120
Abstract: The immune system must be able to respond to a myriad of different threats, each requiring a distinct type of response. Here, we demonstrate that the cytoplasmic lysine deacetylase HDAC7 in macrophages is a metabolic… read more here.
Keywords: inflammatory responses; switch; hdac7; danger signals ... See more keywords
DANGER Signals Activate G-Protein Receptor Kinases Suppressing Neutrophil Function and Predisposing to Infection After Tissue Trauma.
Sign Up to like & getrecommendations! Published in 2023 at "Annals of surgery"
DOI: 10.1097/sla.0000000000005898
Abstract: OBJECTIVE Surgery injures tissue and predisposes to local and systemic infections. We studied injury-induced immune dysfunction seeking novel means to reverse such predisposition. BACKGROUND Injury mobilizes primitive 'DANGER signals' (DAMPs) activating innate immunocyte (neutrophils, PMN)… read more here.
Keywords: function; infection tissue; activate protein; injury ... See more keywords
Targeting Danger Signals to Rescue Fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Respiratory Cell and Molecular Biology"
DOI: 10.1165/rcmb.2022-0022ed
Abstract: lung injury and fibrosis. Exposure to g -radiation, an experimental model of pulmonary fibrosis, can cause tissue injury associated with release of DAMPs. eNAMPT is a novel DAMP that can aggravate proinflammatory responses. Garcia and… read more here.
Keywords: rescue fibrosis; signals rescue; targeting danger; pulmonary fibrosis ... See more keywords
The Delivery of Extracellular “Danger” Signals to Cytosolic Sensors in Phagocytes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.944142
Abstract: Phagocytes, such as macrophages and dendritic cells, possess the ability to ingest large quantities of exogenous material into membrane-bound endocytic organelles such as macropinosomes and phagosomes. Typically, the ingested material, which consists of diverse macromolecules… read more here.
Keywords: endocytic organelles; delivery extracellular; macromolecular danger; danger signals ... See more keywords
Hypochlorous acid selectively promotes toxicity and the expression of danger signals in human abdominal cancer cells
Sign Up to like & getrecommendations! Published in 2021 at "Oncology Reports"
DOI: 10.3892/or.2021.8022
Abstract: Tumors of the abdominal cavity, such as colorectal, pancreatic and ovarian cancer, frequently metastasize into the peritoneum. Large numbers of metastatic nodules hinder curative surgical resection, necessitating lavage with hyperthermic intraperitoneal chemotherapy (HIPEC). However, HIPEC… read more here.
Keywords: danger signals; expression danger; expression; cancer cells ... See more keywords