Dangerous dynamic duo: Lactic acid and PD-1 blockade.
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DOI: 10.1016/j.ccell.2022.01.008
Abstract: In this issue of Cancer Cell, Kumagai et al. reveal lactic acid as a mediator of checkpoint blockade resistance. Tumor-derived lactic acid promotes T regulatory cell (Treg) activity and impairs CD8+ T cell function. PD-1 blockade synergizes… read more here.
Keywords: lactic acid; dangerous dynamic; acid blockade; acid ... See more keywords