Antiarrhythmic effects of dantrolene in human diseased cardiomyocytes.
Sign Up to like & getrecommendations! Published in 2017 at "Heart rhythm"
DOI: 10.1016/j.hrthm.2016.09.014
Abstract: BACKGROUND Cardiac type 2 ryanodine receptors (RyR2s) play a pivotal role in cellular electrophysiology and contractility. Increased RyR2-mediated diastolic sarcoplasmic reticulum (SR) Ca2+ release is linked to heart failure (HF) and arrhythmias. Dantrolene, a drug… read more here.
Keywords: antiarrhythmic effects; dantrolene human; diseased cardiomyocytes; ca2 ... See more keywords