Dapagliflozin attenuates LPS-induced myocardial injury by reducing ferroptosis
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Bioenergetics and Biomembranes"
DOI: 10.1007/s10863-024-10020-3
Abstract: Septic cardiomyopathy is a severe cardiovascular disease with a poor prognosis. Previous studies have reported the involvement of ferroptosis in the pathogenesis of septic cardiomyopathy. SGLT2 inhibitors such as dapagliflozin have been demonstrated to improve… read more here.
Keywords: attenuates lps; ferroptosis; injury; dapagliflozin attenuates ... See more keywords
Dapagliflozin Attenuates Renal Tubulointerstitial Fibrosis Associated With Type 1 Diabetes by Regulating STAT1/TGFβ1 Signaling
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2019.00441
Abstract: Tubulointerstitial fibrosis (TIF) plays an important role in the progression of renal fibrosis in diabetic nephropathy (DN). Accumulating evidence supports a crucial inhibitory effect of dapagliflozin, a SGLT2 inhibitor, on TIF, but the underlying mechanisms… read more here.
Keywords: tubulointerstitial fibrosis; dapagliflozin attenuates; stat1 tgf; fibrosis ... See more keywords