Daphnetin exerts an anticancer effect by attenuating the pro‐inflammatory cytokines
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22759
Abstract: Leukemia is a malignant tissue‐forming disease, which induces the overproduction of large numbers of immature blood cells entering the peripheral blood. It is well documented that inflammation plays a crucial role in the expansion of… read more here.
Keywords: daphnetin; effect; inflammatory cytokines; blood ... See more keywords
Daphnetin attenuates LPS‐induced osteolysis and RANKL mediated osteoclastogenesis through suppression of ERK and NFATc1 pathways
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28408
Abstract: Aseptic prosthetic loosening and periprosthetic infection resulting in inflammatory osteolysis is a leading complication of total joint arthroplasty (TJA). Excessive bone destruction around the bone and prosthesis interface plays a key role in the loosening… read more here.
Keywords: daphnetin; bone; erk nfatc1; osteolysis ... See more keywords
Inhibition of human catechol-O-methyltransferase-mediated dopamine O-methylation by daphnetin and its Phase II metabolites
Sign Up to like & getrecommendations! Published in 2017 at "Xenobiotica"
DOI: 10.1080/00498254.2016.1204567
Abstract: Abstract 1. Finding and developing inhibitors of catechol-O-methyltransferase (COMT) from natural products is highly recommended. Daphnetin, a naturally occurring catechol from the family thymelaeaceae, has a chemical structure similar to several potent COMT inhibitors reported previously.… read more here.
Keywords: daphnetin; daphnetin phase; catechol methyltransferase; comt ... See more keywords
Daphnetin alleviates neuropathic pain in chronic constrictive injury rats via regulating the NF-κB dependent CXCL1/CXCR2 signaling pathway
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2023.2198560
Abstract: Abstract Context Daphnetin is a natural product with anti-inflammatory, antioxidant, and neuroprotective properties. Reports have found that it has a strong analgesic effect; however, its analgesic mechanism is unknown. Objective We explored the effect and… read more here.
Keywords: cxcl1; cxcr2; daphnetin alleviates; neuropathic pain ... See more keywords
Elucidating Antibacterial Activity and Mechanism of Daphnetin against Pseudomonas fluorescens and Shewanella putrefaciens
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DOI: 10.1155/2020/6622355
Abstract: In this research, the antibacterial activity and mechanism of daphnetin against Pseudomonas fluorescens and Shewanella putrefaciens were evaluated. The minimum inhibitory concentration (MIC) of daphnetin on P. fluorescens and S. putrefaciens was 0.16 and 0.08 mg·mL−1,… read more here.
Keywords: daphnetin; activity mechanism; mechanism daphnetin; antibacterial activity ... See more keywords
Nrf2 Signaling Pathway Mediates the Protective Effects of Daphnetin Against D-Galactose Induced-Premature Ovarian Failure
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.810524
Abstract: Oxidative damage can lead to severe ovarian dysfunctions and even premature ovarian failure. Nrf2, a significant transcription factor that regulates the oxidative stress response of cells, declines with age. Daphnetin, as a kind of natural… read more here.
Keywords: daphnetin; premature ovarian; ovarian failure; nrf2 ... See more keywords
Antiplatelet Effect of Daphnetin Is Regulated by cPLA2-Mediated Thromboxane A2 Generation in Mice
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24065779
Abstract: Coumarin derivatives have been recognized for their antithrombotic, anti-inflammatory, and antioxidant properties, and daphnetin is one of the natural coumarin derivatives isolated from Daphne Koreana Nakai. Although the pharmacological value of daphnetin is well documented… read more here.
Keywords: aggregation; txa2 generation; generation; daphnetin ... See more keywords
Regulatory effect of daphnetin on the balance of Th17 and Treg cells in the peripheral blood mononuclear cells from patients with unexplained recurrent pregnancy loss
Sign Up to like & getrecommendations! Published in 2020 at "Central-European Journal of Immunology"
DOI: 10.5114/ceji.2020.103414
Abstract: Introduction There has a close relationship between the balance of T helper 17 (Th17) cells and Foxp3+ regulatory T cells (Treg) and unexplained recurrent pregnancy loss (URPL). The present study is to investigate the regulatory… read more here.
Keywords: th17 treg; treg cells; daphnetin; treg ... See more keywords