Identification and characterization of a new dapoxetine impurity by NMR: Transformation of N‐oxide by Cope elimination
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2016.11.029
Abstract: HIGHLIGHTSA novel dapoxetine impurity has been identified using IR, NMR and MS.The mechanism for the impurity formation was proposed and confirmed by synthesis and degradation studies.The synthesis of dapoxetine‐N‐oxide was completed for the first time.… read more here.
Keywords: degradation; dapoxetine; cope elimination; impurity ... See more keywords
Effect of Wuziyanzong pill on metabolism of dapoxetine in vivo and in vitro
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2018.12.022
Abstract: &NA; In vitro incubation of rat liver microsomes with 30 &mgr;L of 100 &mgr;mol·L−1 dapoxetine and 30 &mgr;L of 10, 100, 250, 500, 1000, 2500, or 5000 &mgr;g·mL−1 Wuziyanzong pill was performed at 37 °C… read more here.
Keywords: dapoxetine; metabolism dapoxetine; group; wuziyanzong pill ... See more keywords
Optimization of taste-masked dapoxetine oral thin films using factorial design: in vitro and in vivo evaluation
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2021.1894445
Abstract: Abstract Dapoxetine HCl is used for the treatment of premature ejaculation. Dapoxetine is primarily metabolized in the liver and kidney and its metabolites are inactive; resulting in reduced bioavailability. Also, one of the commonly encountered… read more here.
Keywords: taste; taste masked; thin films; dapoxetine ... See more keywords
The selective serotonin reuptake inhibitor dapoxetine inhibits voltage‐dependent K+ channels in rabbit coronary arterial smooth muscle cells
Sign Up to like & getrecommendations! Published in 2017 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.12723
Abstract: We investigated the inhibitory effect of dapoxetine, a selective serotonin reuptake inhibitor (SSRI), on voltage‐dependent K+ (Kv) channels using native smooth muscle cells from rabbit coronary arteries. Dapoxetine inhibited Kv channel currents in a concentration‐dependent… read more here.
Keywords: selective serotonin; serotonin reuptake; dapoxetine; voltage dependent ... See more keywords
AB087. Discontinuation of dapoxetine treatment in patients with premature ejaculation: a 2-year prospective observational study
Sign Up to like & getrecommendations! Published in 2018 at "Translational Andrology and Urology"
DOI: 10.21037/tau.2018.ab087
Abstract: Background Although dapoxetine is the only oral pharmacological agent approved for the treatment of premature ejaculation (PE), and is very effective, the discontinuation rate is high. We assessed the discontinuation rate in patients with PE,… read more here.
Keywords: dapoxetine; treatment; reasons discontinuation; time ... See more keywords
Determination of Dapoxetine Hydrochloride in Human Plasma by HPLC–MS/MS and Its Application in a Bioequivalence Study
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DOI: 10.3390/molecules27092707
Abstract: Dapoxetine is used for the treatment of premature ejaculation. The present study developed an HPLC–MS/MS method to determine the levels of dapoxetine in human plasma processed using simple protein precipitation. Dapoxetine-d7 was selected as the… read more here.
Keywords: human plasma; hplc; determination dapoxetine; dapoxetine ... See more keywords
Aerobic exercise improves ejaculatory behaviors and complements dapoxetine treatment by upregulating the BDNF-5-HT duo: a pilot study in rats.
Sign Up to like & getrecommendations! Published in 2023 at "Asian journal of andrology"
DOI: 10.4103/aja2022121
Abstract: Accumulating evidence has revealed many clues that regular aerobic exercise benefits brain health and behaviors. The aims of this study were to explore the effect of aerobic exercise on ejaculatory behaviors, as well as to… read more here.
Keywords: aerobic exercise; bdnf; treatment; dapoxetine ... See more keywords