Identification and characterization of a new dapoxetine impurity by NMR: Transformation of N‐oxide by Cope elimination
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DOI: 10.1016/j.jpba.2016.11.029
Abstract: HIGHLIGHTSA novel dapoxetine impurity has been identified using IR, NMR and MS.The mechanism for the impurity formation was proposed and confirmed by synthesis and degradation studies.The synthesis of dapoxetine‐N‐oxide was completed for the first time.… read more here.
Keywords: degradation; dapoxetine; cope elimination; impurity ... See more keywords