Cyclic Lipopeptide Antibiotic Daptomycin Electrochemical Oxidation at a Glassy Carbon Electrode
Sign Up to like & getrecommendations! Published in 2017 at "Electroanalysis"
DOI: 10.1002/elan.201700037
Abstract: Daptomycin was the first approved drug from a new class of antimicrobials, the cyclic lipopeptides, and presents a broad spectrum of activity against a wide range of gram-positive bacteria. The daptomycin redox behaviour, by cyclic,… read more here.
Keywords: glassy carbon; daptomycin; oxidation; carbon electrode ... See more keywords
Degradation mechanism of AtrA mediated by ClpXP and its application in daptomycin production in Streptomyces roseosporus
Sign Up to like & getrecommendations! Published in 2023 at "Protein Science"
DOI: 10.1002/pro.4617
Abstract: The efficiency of drug biosynthesis depends on different transcriptional regulatory pathways in Streptomyces, and the protein degradation system adds another layer of complexity to the regulatory processes. AtrA, a transcriptional regulator in the A‐factor regulatory… read more here.
Keywords: mechanism atra; daptomycin; production; degradation mechanism ... See more keywords
Molecular State of the Membrane-Active Antibiotic Daptomycin.
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical journal"
DOI: 10.1016/j.bpj.2017.05.025
Abstract: Membrane-active antibiotics are potential alternatives to the resistance-prone conventional antibiotics. Daptomycin, a cyclic lipopeptide, is the only membrane-active antibiotic approved by the U.S. Food and Drug Administration so far. The drug interacts with the cytoplasmic… read more here.
Keywords: membrane active; membrane binding; calcium; daptomycin ... See more keywords
Current use of daptomycin and systematic therapeutic drug monitoring: Clinical experience in a tertiary care institution.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2018.09.015
Abstract: Therapeutic drug monitoring (TDM) could optimise daptomycin use. However, no validated serum target levels have been established. This prospective study at a tertiary centre including hospitalised patients receiving daptomycin aimed to evaluate the adequacy of… read more here.
Keywords: use; therapeutic drug; serum levels; daptomycin ... See more keywords
Synthesis of gold nanoflowers stabilized with amphiphilic daptomycin for enhanced photothermal antitumor and antibacterial effects.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119231
Abstract: The development of effective agents for cancer therapy and inhibition of bacterial infection has drawn a great deal of interest. Photothermal therapy has been widely used for the thermal ablation of tumor cells. In addition,… read more here.
Keywords: gold nanoflowers; photothermal antitumor; antitumor antibacterial; daptomycin ... See more keywords
Comparison of the Effects of Daptomycin on Bacterial and Model Membranes.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b00818
Abstract: Daptomycin is a phosphatidylglycerol specific, calcium-dependent membrane-active antibiotic that has been approved for the treatment of Gram-positive infections. A recent Bacillus subtilis study found that daptomycin clustered into fluid lipid domains of bacterial membranes and… read more here.
Keywords: ion leakage; daptomycin; phase; membrane ... See more keywords
Discovery of Highly Active Derivatives of Daptomycin by Assessing the Effect of Amino Acid Substitutions at Positions 8 and 11 on a Daptomycin Analogue.
Sign Up to like & getrecommendations! Published in 2022 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.1c00483
Abstract: Daptomycin is an important antibiotic used for treating serious infections caused by Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci. Establishing structure-activity relationships of daptomycin is important for developing new daptomycin-based antibiotics with… read more here.
Keywords: positions daptomycin; daptomycin; effect amino; activity ... See more keywords
Daptomycin Pore Formation Is Restricted by Lipid Acyl Chain Composition.
Sign Up to like & getrecommendations! Published in 2017 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.7b00138
Abstract: Daptomycin is a calcium-dependent lipopeptide antibiotic that is used clinically against various Gram-positive pathogens. It acts on bacterial cell membranes, whose susceptibility varies with the content of phosphatidylglycerol (PG). Some studies have reported that daptomycin… read more here.
Keywords: formation restricted; lipid acyl; restricted lipid; daptomycin ... See more keywords
Association between daptomycin susceptibility and teicoplanin resistance in Staphylococcus epidermidis
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-55149-z
Abstract: Staphylococcus epidermidis infections are a common occurrence in hospitals, particularly in catheter-related bloodstream and surgical site infections and infective endocarditis. Higher daptomycin minimum inhibitory concentration (MIC) values may be associated with daptomycin treatment failure among… read more here.
Keywords: daptomycin susceptibility; epidermidis infections; staphylococcus epidermidis; resistance ... See more keywords
A pharmacovigilance study of daptomycin use in infants under 1 year old based on the FDA adverse event reporting system
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-24217-y
Abstract: The safety of daptomycin in infants under 1 year old remains uncertain. This study aimed to identify signals potentially associated with daptomycin use in this special population based on the Food and Drug Administration adverse… read more here.
Keywords: system; ror; year old; daptomycin ... See more keywords
Optimization of dosing regimens of vancomycin, teicoplanin, linezolid and daptomycin against methicillin-resistant Staphylococcus aureus in neutropenic patients with cancer by Monte Carlo simulations
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Chemotherapy"
DOI: 10.1080/1120009x.2021.1931758
Abstract: The objective of this study was to evaluate the efficacy of various dosing regimens of vancomycin, teicoplanin, linezolid and daptomycin against methicillin-resistant Staphylococcus aureus (MRSA) in neutropenic patients with cancer. Monte Carlo simulations were conducted… read more here.
Keywords: patients cancer; dosing regimens; regimens vancomycin; vancomycin teicoplanin ... See more keywords