Cyclic Lipopeptide Antibiotic Daptomycin Electrochemical Oxidation at a Glassy Carbon Electrode
Sign Up to like & getrecommendations! Published in 2017 at "Electroanalysis"
DOI: 10.1002/elan.201700037
Abstract: Daptomycin was the first approved drug from a new class of antimicrobials, the cyclic lipopeptides, and presents a broad spectrum of activity against a wide range of gram-positive bacteria. The daptomycin redox behaviour, by cyclic,… read more here.
Keywords: glassy carbon; daptomycin; oxidation; carbon electrode ... See more keywords
Degradation mechanism of AtrA mediated by ClpXP and its application in daptomycin production in Streptomyces roseosporus
Sign Up to like & getrecommendations! Published in 2023 at "Protein Science"
DOI: 10.1002/pro.4617
Abstract: The efficiency of drug biosynthesis depends on different transcriptional regulatory pathways in Streptomyces, and the protein degradation system adds another layer of complexity to the regulatory processes. AtrA, a transcriptional regulator in the A‐factor regulatory… read more here.
Keywords: mechanism atra; daptomycin; production; degradation mechanism ... See more keywords
Molecular State of the Membrane-Active Antibiotic Daptomycin.
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical journal"
DOI: 10.1016/j.bpj.2017.05.025
Abstract: Membrane-active antibiotics are potential alternatives to the resistance-prone conventional antibiotics. Daptomycin, a cyclic lipopeptide, is the only membrane-active antibiotic approved by the U.S. Food and Drug Administration so far. The drug interacts with the cytoplasmic… read more here.
Keywords: membrane active; membrane binding; calcium; daptomycin ... See more keywords
Current use of daptomycin and systematic therapeutic drug monitoring: Clinical experience in a tertiary care institution.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2018.09.015
Abstract: Therapeutic drug monitoring (TDM) could optimise daptomycin use. However, no validated serum target levels have been established. This prospective study at a tertiary centre including hospitalised patients receiving daptomycin aimed to evaluate the adequacy of… read more here.
Keywords: use; therapeutic drug; serum levels; daptomycin ... See more keywords
Synthesis of gold nanoflowers stabilized with amphiphilic daptomycin for enhanced photothermal antitumor and antibacterial effects.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119231
Abstract: The development of effective agents for cancer therapy and inhibition of bacterial infection has drawn a great deal of interest. Photothermal therapy has been widely used for the thermal ablation of tumor cells. In addition,… read more here.
Keywords: gold nanoflowers; photothermal antitumor; antitumor antibacterial; daptomycin ... See more keywords
Comparison of the Effects of Daptomycin on Bacterial and Model Membranes.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b00818
Abstract: Daptomycin is a phosphatidylglycerol specific, calcium-dependent membrane-active antibiotic that has been approved for the treatment of Gram-positive infections. A recent Bacillus subtilis study found that daptomycin clustered into fluid lipid domains of bacterial membranes and… read more here.
Keywords: ion leakage; daptomycin; phase; membrane ... See more keywords
Discovery of Highly Active Derivatives of Daptomycin by Assessing the Effect of Amino Acid Substitutions at Positions 8 and 11 on a Daptomycin Analogue.
Sign Up to like & getrecommendations! Published in 2022 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.1c00483
Abstract: Daptomycin is an important antibiotic used for treating serious infections caused by Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci. Establishing structure-activity relationships of daptomycin is important for developing new daptomycin-based antibiotics with… read more here.
Keywords: positions daptomycin; daptomycin; effect amino; activity ... See more keywords
Daptomycin Pore Formation Is Restricted by Lipid Acyl Chain Composition.
Sign Up to like & getrecommendations! Published in 2017 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.7b00138
Abstract: Daptomycin is a calcium-dependent lipopeptide antibiotic that is used clinically against various Gram-positive pathogens. It acts on bacterial cell membranes, whose susceptibility varies with the content of phosphatidylglycerol (PG). Some studies have reported that daptomycin… read more here.
Keywords: formation restricted; lipid acyl; restricted lipid; daptomycin ... See more keywords
Association between daptomycin susceptibility and teicoplanin resistance in Staphylococcus epidermidis
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-55149-z
Abstract: Staphylococcus epidermidis infections are a common occurrence in hospitals, particularly in catheter-related bloodstream and surgical site infections and infective endocarditis. Higher daptomycin minimum inhibitory concentration (MIC) values may be associated with daptomycin treatment failure among… read more here.
Keywords: daptomycin susceptibility; epidermidis infections; staphylococcus epidermidis; resistance ... See more keywords
Optimization of dosing regimens of vancomycin, teicoplanin, linezolid and daptomycin against methicillin-resistant Staphylococcus aureus in neutropenic patients with cancer by Monte Carlo simulations
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Chemotherapy"
DOI: 10.1080/1120009x.2021.1931758
Abstract: The objective of this study was to evaluate the efficacy of various dosing regimens of vancomycin, teicoplanin, linezolid and daptomycin against methicillin-resistant Staphylococcus aureus (MRSA) in neutropenic patients with cancer. Monte Carlo simulations were conducted… read more here.
Keywords: patients cancer; dosing regimens; regimens vancomycin; vancomycin teicoplanin ... See more keywords
Importance of daptomycin dosage on the clinical outcome in liver transplant recipients with vancomycin-resistant enterococci infection
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Chemotherapy"
DOI: 10.1080/1120009x.2022.2031470
Abstract: Abstract We retrospectively studied 16 (3 colonization and 13 infections) early post-liver transplant (≤60-day after transplantation) patients with vancomycin-resistant enterococci (VRE) colonization/infection from 2016 to 2019. All VRE isolates were Enterococcus faecium. Of 13 patients… read more here.
Keywords: liver transplant; daptomycin; vancomycin resistant; infection ... See more keywords