Studies on daptomycin lactam‐based analogues
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Peptide Science"
DOI: 10.1002/psc.3430
Abstract: Herein, we report the synthesis and antibacterial evaluation of a series of daptomycin lactam‐based analogues. As compared with daptomycin, the daptomycin analogue with singly modified lactam has an eightfold increase in its minimum inhibitory concentration… read more here.
Keywords: antibacterial activity; based analogues; lactam based; daptomycin lactam ... See more keywords
Failure of daptomycin β-Lactam combination therapy to prevent resistance emergence in Enterococcus faecium.
Sign Up to like & getrecommendations! Published in 2018 at "Diagnostic microbiology and infectious disease"
DOI: 10.1016/j.diagmicrobio.2017.10.017
Abstract: Daptomycin β-Lactam combination therapy offers "protection" against daptomycin non-susceptibility (DNS) development in Enterococcus faecium. We report failure of this strategy and the importance of source control. Mutations were detected in the LiaF and cls genes… read more here.
Keywords: lactam combination; combination therapy; daptomycin lactam; enterococcus faecium ... See more keywords