Accurate determination of drug-to-antibody ratio of interchain cysteine-linked antibody–drug conjugates by LC-HRMS
Sign Up to like & getrecommendations! Published in 2019 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-019-02280-5
Abstract: Accurate determination of the drug-to-antibody ratio (DAR) of interchain cysteine-linked antibody–drug conjugates (ADCs) is challenging. High-resolution mass spectrometry (HRMS) analysis of the ADCs at the intact or subunit level provides a feasible way to measure… read more here.
Keywords: dar; cysteine linked; accurate determination; drug ... See more keywords
Interobserver and intraobserver reliability of determining the deformity angular ratio in severe pediatric deformity curves.
Sign Up to like & getrecommendations! Published in 2020 at "Spine deformity"
DOI: 10.1007/s43390-020-00239-6
Abstract: STUDY DESIGN Cross-sectional reliability study. OBJECTIVE The deformity angular ratio (DAR) is a means of quantifying magnitude of the coronal (C-DAR) and sagittal (S-DAR) plane of deformity curves to produce a total DAR (T-DAR). It… read more here.
Keywords: dar dar; range; dar; deformity angular ... See more keywords
DAR-901 vaccine for the prevention of infection with Mycobacterium tuberculosis among BCG-immunized adolescents in Tanzania: A randomized controlled, double-blind phase 2b trial.
Sign Up to like & getrecommendations! Published in 2020 at "Vaccine"
DOI: 10.1016/j.vaccine.2020.09.055
Abstract: BACKGROUND SRL172 prevented disease due to Mycobacterium tuberculosis in a Phase 3 trial. DAR-901 represents a scalable manufacturing process for SRL172. We sought to determine if DAR-901 would prevent infection with M. tuberculosis among BCG-primed… read more here.
Keywords: dar 901; trial; dar; infection ... See more keywords
Results from TRIO030, a pre-surgical tissue-acquisition study to evaluate molecular alterations in human breast cancer tissue following short-term exposure to the androgen receptor antagonist darolutamide
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdz239.076
Abstract: Abstract Background The role of the androgen receptor (AR) in breast cancer (BC) is not fully elucidated. TRIO030 was conducted to identify molecular changes in BC tissue following short-term exposure to darolutamide (DAR), a new… read more here.
Keywords: dar; exposure; tissue; androgen receptor ... See more keywords
Learning from Ambiguous Labels for Lung Nodule Malignancy Prediction
Sign Up to like & getrecommendations! Published in 2022 at "IEEE transactions on medical imaging"
DOI: 10.1109/tmi.2022.3149344
Abstract: Lung nodule malignancy prediction is an essential step in the early diagnosis of lung cancer. Besides the difficulties commonly discussed, the challenges of this task also come from the ambiguous labels provided by annotators, since… read more here.
Keywords: nodule malignancy; malignancy prediction; set set; prediction ... See more keywords
Different Degrees of 5'-to-3' DAR Interactions Modulate Zika Virus Genome Cyclization and Host-Specific Replication
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Virology"
DOI: 10.1128/jvi.01602-19
Abstract: Flaviviruses naturally cycle between the mosquito vector and vertebrate hosts. The disparate hosts provide selective pressures that drive virus genome evolution to maintain efficient replication during host alteration. Host adaptation may occur at different stages… read more here.
Keywords: replication; mosquito; host specific; genome cyclization ... See more keywords
Delayed aneurysm rupture after flow-diverter deployment in unruptured aneurysms: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2025 at "Journal of NeuroInterventional Surgery"
DOI: 10.1136/jnis-2025-024135
Abstract: Background Delayed aneurysm rupture (DAR) is a potentially devastating complication after flow-diverters (FD) deployment and their exact mechanisms are still unclear. The purpose of this meta-analysis is to synthesize the latest evidence on DAR after… read more here.
Keywords: aneurysm rupture; meta analysis; meta; dar ... See more keywords
Abstract 2614: GlycoConnect™ ADC toolbox expansion with high DAR technology
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-2614
Abstract: Recently topoisomerase 1 inhibitors have gained significant traction as a cytotoxic payload for ADCs based on the clinical success of camptothecin-based ADCs Enhertu® (DXd) and Trodelvy® (SN-38). In contrast to the majority of other approved… read more here.
Keywords: technology; adc toolbox; glycoconnect adc; drug ... See more keywords
Abstract 5731: BGB-C354, a novel B7H3 ADC with high DAR stability and strong bystander effect, demonstrates robust antitumor activity in preclinical models
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-5731
Abstract: B7H3 is a type I transmembrane protein belonging to the B7 immunoregulatory family. B7H3 is overexpressed on a wide range of solid tumors such as lung cancers, gastrointestinal cancers and gynecological cancers, but its expression… read more here.
Keywords: bgb c354; dar; b7h3; activity ... See more keywords
Transverse vibration of laminated-composite-plates with fillers under moving mass rested on elastic foundation using higher order shear deformation theory
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science"
DOI: 10.1177/09544062241256589
Abstract: Usually, the laminated-composite-plates (LCPs) are strengthened by altering the constituents. The use of nano-particles as filler is a new approach in this regard. Here, flyash and graphene are used as fillers in epoxy-based woven E-glass… read more here.
Keywords: composite plates; moving mass; laminated composite; dar ... See more keywords
Development of an Allogeneic Anti-Bcma T Cell Therapy Utilizing a Novel Dimeric Antigen Receptor (DAR) Structure
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-131892
Abstract: Background: Multiple myeloma remains an incurable malignancy of plasma cells. Adoptive transfer of chimeric antigen receptor (CAR)-expressing T cells is a promising new therapy for hematologic malignancies. B-cell maturation antigen (BCMA) is a protein that… read more here.
Keywords: anti bcma; equity ownership; dar;