Structural characterization of a monomethylauristatin-E based ADC that contains 8 drugs conjugated at interchain cysteine residues.
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DOI: 10.1016/j.jpba.2021.114309
Abstract: Antibody-drug conjugates (ADCs) with a drug-to-antibody ratio (DAR) of 8 are attractive as therapeutic anti-cancer agents due to the higher levels of cytotoxic payload delivered to tumors. Biophysical characterization of a DAR 8 ADC fully… read more here.
Keywords: dar adc; conjugated interchain; cysteine residues; stability ... See more keywords