Secreted mitochondrial aspartyl‐tRNA synthetase (DARS2) regulates TNFα signaling
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DOI: 10.14814/phy2.70627
Abstract: Aminoacyl‐tRNA Synthetases (aaRS) are important regulators of cytokine signaling. Multiple cytoplasmic aaRS family members have been observed to be secreted in response to various stimuli to modulate downstream responses, however, agonist‐induced cellular release of aaRS… read more here.
Keywords: aspartyl trna; dars2; trna; trna synthetase ... See more keywords
MicroRNA (let-7b-5p)-targeted DARS2 regulates lung adenocarcinoma growth by PI3K/AKT signaling pathway
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DOI: 10.32604/or.2023.030293
Abstract: Background The aberrant intracellular expression of a mitochondrial aspartyl-tRNA synthetase 2 (DARS2) has been reported in human cancers. Nevertheless, its critical role and detailed mechanism in lung adenocarcinoma (LUAD) remain unexplored. Methods Initially, The Cancer… read more here.
Keywords: dars2; lung adenocarcinoma; akt signaling; expression ... See more keywords