Prediction of Fetal Darunavir Exposure by Integrating Human Ex-Vivo Placental Transfer and Physiologically Based Pharmacokinetic Modeling
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Pharmacokinetics"
DOI: 10.1007/s40262-017-0583-8
Abstract: BackgroundFetal antiretroviral exposure is usually derived from the cord-to-maternal concentration ratio. This static parameter does not provide information on the pharmacokinetics in utero, limiting the assessment of a fetal exposure–effect relationship.ObjectiveThe aim of this study… read more here.
Keywords: based pharmacokinetic; darunavir; exposure; physiologically based ... See more keywords
Exploration of Reduced Doses and Short-Cycle Therapy for Darunavir/Cobicistat in Patients with HIV Using Population Pharmacokinetic Modeling and Simulations
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DOI: 10.1007/s40262-020-00920-z
Abstract: Protease inhibitors such as darunavir are an important therapeutic option in the anti-human immunodeficiency virus arsenal. Current dosage guidelines recommend using cobicistat- or ritonavir-boosted darunavir 800 mg every 24 h (q24h) in protease inhibitor-naïve patients,… read more here.
Keywords: pharmacokinetic modeling; darunavir; population pharmacokinetic; using population ... See more keywords
Effect of body weight and composition on efavirenz, atazanavir or darunavir concentration.
Sign Up to like & getrecommendations! Published in 2018 at "Therapie"
DOI: 10.1016/j.therap.2017.08.007
Abstract: BACKGROUND To compare the steady state plasma concentrations (Css) of three antiretroviral drugs in both normal and overweight patients, and to determine the relationship between Css and fat mass (FM) or lean body mass. METHODS… read more here.
Keywords: darunavir; effect; composition; concentration ... See more keywords
Inhibition of HIV-1 Protease by a Boronic Acid with High Oxidative Stability.
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DOI: 10.1021/acsmedchemlett.2c00464
Abstract: HIV-1 protease is an important target for pharmaceutical intervention in HIV infection. Extensive structure-based drug design led to darunavir becoming a key chemotherapeutic agent. We replaced the aniline group of darunavir with a benzoxaborolone to… read more here.
Keywords: hiv; hiv protease; inhibition hiv; darunavir ... See more keywords
Prevalence of Darunavir Resistance in the United States from 2010 to 2017
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DOI: 10.1089/aid.2018.0100
Abstract: Abstract The emergence and transmission of antiretroviral drug resistance have been and remain a concern among people living with human immunodeficiency virus (HIV)-1 infection. The protease inhibitor (PI) darunavir has been approved for use in… read more here.
Keywords: darunavir resistance; darunavir; prevalence; 2010 2017 ... See more keywords
Pharmacokinetics of darunavir/cobicistat and etravirine alone and co-administered in HIV-infected patients
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkx459
Abstract: Objectives To determine the effect of etravirine on the pharmacokinetics of darunavir/cobicistat and vice versa. Safety and tolerability of this combination were also evaluated. Methods Open-label, fixed-sequence trial in two cohorts of HIV-infected patients on… read more here.
Keywords: darunavir cobicistat; darunavir; cohort; pharmacokinetics darunavir ... See more keywords
Atazanavir and darunavir in pregnant women with HIV: evaluation of laboratory and clinical outcomes from an observational national study
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DOI: 10.1093/jac/dkx478
Abstract: Background Atazanavir and darunavir represent the main HIV PIs recommended in pregnancy, but comparative data in pregnant women are limited. We assessed the safety and activity profile of these two drugs in pregnancy using data… read more here.
Keywords: pregnancy; atazanavir darunavir; darunavir; pregnant women ... See more keywords
Pharmacokinetic modelling of darunavir/ritonavir dose reduction (800/100 to 400/100 mg once daily) in a darunavir/ritonavir-containing regimen in virologically suppressed HIV-infected patients: ANRS 165 DARULIGHT sub-study
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DOI: 10.1093/jac/dky193
Abstract: Background In the ANRS 165 DARULIGHT study (NCT02384967) carried out in HIV-infected patients, the use of a darunavir/ritonavir-containing regimen with a switch to a reduced dose of darunavir maintained virological efficacy (≤50 copies/mL) for 48 weeks with… read more here.
Keywords: darunavir ritonavir; containing regimen; darunavir; 800 100 ... See more keywords
Evaluating darunavir/ritonavir dosing regimens for HIV-positive pregnant women using semi-mechanistic pharmacokinetic modelling
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DOI: 10.1093/jac/dky567
Abstract: Background Darunavir 800 mg once (q24h) or 600 mg twice (q12h) daily combined with low-dose ritonavir is used to treat HIV-positive pregnant women. Decreased total darunavir exposure (17%-50%) has been reported during pregnancy, but limited data on… read more here.
Keywords: positive pregnant; darunavir ritonavir; darunavir; exposure ... See more keywords
Week 96 results of a phase 3 trial of darunavir/cobicistat/emtricitabine/tenofovir alafenamide in treatment-naïve HIV-1 patients.
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DOI: 10.1097/qad.0000000000002463
Abstract: BACKGROUND Darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) 800/150/200/10mg was investigated through 96 weeks in AMBER (NCT02431247). METHODS Treatment-naïve, HIV-1-positive adults (screening plasma viral load [VL]≥1000 copies/ml; CD4 count >50 cells/mm) were randomized (1:1) to D/C/F/TAF (N=362) or D/C… read more here.
Keywords: week results; emtricitabine tenofovir; darunavir; tenofovir ... See more keywords
Analytical Techniques in the Analysis of Darunavir and Ritonavir: A Review
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DOI: 10.2174/1573412915666190206124808
Abstract: Darunavir and Ritonavir are amongst the most useful antiretroviral drugs worldwide for treating AIDS (acquired immune deficiency syndrome). This review discussed and summarized the various analytical techniques used in the qualitative and quantitative analysis of… read more here.
Keywords: darunavir; analysis darunavir; analytical techniques; darunavir ritonavir ... See more keywords