Pharmacokinetics of darunavir/cobicistat and etravirine alone and co-administered in HIV-infected patients
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DOI: 10.1093/jac/dkx459
Abstract: Objectives To determine the effect of etravirine on the pharmacokinetics of darunavir/cobicistat and vice versa. Safety and tolerability of this combination were also evaluated. Methods Open-label, fixed-sequence trial in two cohorts of HIV-infected patients on… read more here.
Keywords: darunavir cobicistat; darunavir; cohort; pharmacokinetics darunavir ... See more keywords
Pharmacokinetics of dolutegravir with and without darunavir/cobicistat in healthy volunteers
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DOI: 10.1093/jac/dky384
Abstract: Background Dolutegravir combined with darunavir/cobicistat is a promising NRTI-sparing and/or salvage strategy for the treatment of HIV-1 infection. Methods This Phase I, open-label, 57 day, crossover, pharmacokinetic (PK) study, enrolled healthy volunteers aged 18-65 years, who were… read more here.
Keywords: darunavir cobicistat; healthy volunteers; cobicistat; drv cobi ... See more keywords
Use of Darunavir-Cobicistat as a Treatment Option for Critically Ill Patients with SARS-CoV-2 Infection
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DOI: 10.3349/ymj.2020.61.9.826
Abstract: We retrospectively reviewed patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections who were admitted to an intensive care unit in Daegu, South Korea. The outcomes of patients who did (cases) or did not… read more here.
Keywords: darunavir cobicistat; cobicistat; critically ill; cobicistat group ... See more keywords