Effects of the pleiotropic regulator DasR on lincomycin production in Streptomyces lincolnensis
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DOI: 10.1007/s00253-024-13201-7
Abstract: Abstract The lincoamide antibiotic lincomycin, derived from Streptomyces lincolnensis , is widely used for the treatment of infections caused by gram-positive bacteria. As a common global regulatory factor of GntR family, DasR usually exists as… read more here.
Keywords: lincolnensis; dasr; regulator; lincomycin production ... See more keywords
Transcriptional Regulator DasR Represses Daptomycin Production through Both Direct and Cascade Mechanisms in Streptomyces roseosporus
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DOI: 10.3390/antibiotics11081065
Abstract: Daptomycin, produced by Streptomyces roseosporus, is a clinically important cyclic lipopeptide antibiotic used for the treatment of human infections caused by drug-resistant Gram-positive pathogens. In contrast to most Streptomyces antibiotic biosynthetic gene clusters (BGCs), daptomycin… read more here.
Keywords: production; daptomycin production; streptomyces roseosporus; dasr ... See more keywords