Toward Reducing hERG Affinities for DAT Inhibitors with a Combined Machine Learning and Molecular Modeling Approach
Sign Up to like & getrecommendations! Published in 2021 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.1c00856
Abstract: Psychostimulant drugs, such as cocaine, inhibit dopamine reuptake via blockading the dopamine transporter (DAT), which is the primary mechanism underpinning their abuse. Atypical DAT inhibitors are dissimilar to cocaine and can block cocaine- or methamphetamine-induced… read more here.
Keywords: molecular modeling; machine learning; atypical dat; dat inhibitors ... See more keywords
Oral modafinil facilitates intracranial self-stimulation in rats: comparison with methylphenidate
Sign Up to like & getrecommendations! Published in 2017 at "Behavioural Pharmacology"
DOI: 10.1097/fbp.0000000000000288
Abstract: Modafinil is a low-potency inhibitor of dopamine transporters (DAT) approved clinically to promote wakefulness. In most procedures used for abuse-liability assessment, modafinil produces effects similar to those of abused DAT inhibitors such as cocaine and… read more here.
Keywords: intracranial self; self stimulation; stimulation; modafinil ... See more keywords