Aspirin as a Potential Geroprotector: Experimental Data and Clinical Evidence.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-55035-6_11
Abstract: Aging is a biological process with effects at the molecular, cellular, tissue, organ, system, and organismal levels and is characterized by decline in physical function and higher risks of age-related diseases. The use of anti-aging… read more here.
Keywords: data clinical; evidence; experimental data; potential geroprotector ... See more keywords
Big Data vs. Clinical Trials in HPB Surgery
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Gastrointestinal Surgery"
DOI: 10.1007/s11605-020-04536-3
Abstract: Randomized controlled clinical trials (RCTs) are at the heart of “evidence-based” medicine. However, in surgical practice, RCTs remain uncommon. Conducting well-designed RCTs for surgical procedures is often challenged by inadequate recruitment accrual, blinding, or standardization… read more here.
Keywords: big data; data clinical; surgery big; clinical trials ... See more keywords
Insights Into Oropharyngeal Dysphagia From Administrative Data and Clinical Registries: A Literature Review.
Sign Up to like & getrecommendations! Published in 2018 at "American journal of speech-language pathology"
DOI: 10.1044/2018_ajslp-17-0158
Abstract: Purpose The call for data-driven health care has been bolstered by the digitization of medical records, quality initiatives, and payment reform. Administrative databases and clinical registries are increasingly being used to study oropharyngeal dysphagia and… read more here.
Keywords: oropharyngeal dysphagia; clinical registries; data clinical; quality evidence ... See more keywords
Power and Challenges of Big Data: Why Clinical Researchers Should Not Be Ignored
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neurosurgical Anesthesiology"
DOI: 10.1097/ana.0000000000000658
Abstract: 2008) to create a robust predictive model for perioperative stroke, also identifying an 8-fold increase in perioperative mortality. Subsequently, Jørgensen et al8 used 481,183 surgical cases from the Danish National Patient Register to establish that… read more here.
Keywords: data clinical; challenges big; power challenges; power ... See more keywords
Estimands and missing data in clinical trials of chronic pain treatments: advances in design and analysis.
Sign Up to like & getrecommendations! Published in 2020 at "Pain"
DOI: 10.1097/j.pain.0000000000001937
Abstract: In clinical trials of treatments for chronic pain, the percentage of participants who withdraw early can be as high as 50%. Major reasons for early withdrawal in these studies include perceived lack of efficacy and… read more here.
Keywords: analysis; data clinical; clinical trials; missing data ... See more keywords
Missing data in clinical research: an integrated approach
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Dermatology"
DOI: 10.1111/bjd.16010
Abstract: Linked Article: Mason et al. Br J Dermatol 2017; 177:1527–36. read more here.
Keywords: integrated approach; dermatology; data clinical; research integrated ... See more keywords
Diagnosing fraudulent baseline data in clinical trials
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0239121
Abstract: The first table in many articles reporting results of a randomized clinical trial compares baseline factors across arms. Results that appear inconsistent with chance trigger suspicion, and in one case, accusation and confirmation of data… read more here.
Keywords: data clinical; diagnosing fraudulent; baseline data; clinical trials ... See more keywords
Exporting Data from a Clinical Data Warehouse
Sign Up to like & getrecommendations! Published in 2018 at "Studies in health technology and informatics"
DOI: 10.3233/978-1-61499-858-7-88
Abstract: Data Warehouses (DW) are useful tools to support clinical studies as they can provide exports of routine care data for scientific reuse. Exported DW data is usually post-processed and integrated into study databases by study… read more here.
Keywords: exporting data; data warehouse; data clinical; clinical data ... See more keywords
Designed Learning: Missing Data in Clinical Research
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Internal Medicine"
DOI: 10.7326/m18-0534
Abstract: Countless articles and textbooks have been written on the topic of missing data. In 2010, the National Research Council published recommendations for the prevention and treatment of missing data in clinical trials, which were developed… read more here.
Keywords: research; data clinical; designed learning; learning missing ... See more keywords