Binding of anticancer drug daunomycin to parallel G-quadruplex DNA [d-(TTGGGGT)]4 leads to thermal stabilization: A multispectroscopic investigation.
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DOI: 10.1016/j.ijbiomac.2018.09.154
Abstract: Guanine rich DNA sequences form four stranded G-quadruplex structures found in telomeric DNA and oncogene promoters. Small molecules binding and stabilizing the G-quadruplex disrupt telomere maintenance and gene regulation, thereby limiting the proliferation of cancer… read more here.
Keywords: thermal stabilization; daunomycin; dna; quadruplex dna ... See more keywords