Synthesis of daunorubicin conjugates with fragments of H type 5, Lea, Lex antigens and N-fucoglycan
Sign Up to like & getrecommendations! Published in 2019 at "Russian Chemical Bulletin"
DOI: 10.1007/s11172-019-2708-8
Abstract: Daunorubicin was conjugated with spacered N-glycosides of di- and trisaccharides containing terminal α-l-fucopyranose residues. The synthesis was carried out by N-monoalkylation of daunorubicin hydrochloride (1) in aqueous DMF in the presence of NaHCO3 using N-β-glycoside… read more here.
Keywords: fragments type; lea lex; lex antigens; type lea ... See more keywords
Anti-CD123 antibody-modified niosomes for targeted delivery of daunorubicin against acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2017 at "Drug Delivery"
DOI: 10.1080/10717544.2017.1333170
Abstract: Abstract A novel niosomal delivery system was designed and investigated for the targeted delivery of daunorubicin (DNR) against acute myeloid leukemia (AML). Anti-CD123 antibodies conjugated to Mal-PEG2000-DSPE were incorporated into normal niosomes (NS) via a… read more here.
Keywords: antibody; cd123; anti cd123; daunorubicin ... See more keywords
Cytarabine and daunorubicin for the treatment of acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2017.1391216
Abstract: ABSTRACT Introduction: Acute myeloid leukemia (AML) is the most common acute forms of leukemia in adults. It has a poor long-term survival with a high relapse rate and at relapse, is commonly resistant to available… read more here.
Keywords: daunorubicin; myeloid leukemia; cytarabine; acute myeloid ... See more keywords
Daunorubicin-induced arterial stiffness in Down syndrome
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733537
Abstract: Children with Down syndrome have a high risk of leukemia and are at a higher risk for delayed early onset heart failure after treatment. Cardiac toxicity is more severe in female patients. Traditional risk factors… read more here.
Keywords: ts65dn mice; ts65dn; daunorubicin; physiology ... See more keywords
Induction Therapy for AML with 90 Mg/m² Daunorubicin Results in Higher Troponin T Serum Levels in Comparison to Treatment with 60 Mg/m² Daunorubicin
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood.v130.suppl_1.3901.3901
Abstract: Introduction : Induction therapy for acute myeloid leukemia (AML) based on 7 days of cytarabine and 3 days of anthracycline has been standard treatment for decades. However, the optimal dose level of anthracycline is still… read more here.
Keywords: daunorubicin; induction; induction therapy; research funding ... See more keywords
Self-Assembled Daunorubicin/Epigallocatechin Gallate Nanocomplex for Synergistic Reversal of Chemoresistance in Leukemia
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24010381
Abstract: Chemoresistance is one of the major challenges for the treatment of acute myeloid leukemia. Epigallocatechin gallate (EGCG), a bioactive polyphenol from green tea, has attracted immense interest as a potential chemosensitizer, but its application is… read more here.
Keywords: daunorubicin; epigallocatechin gallate; leukemia; self assembled ... See more keywords
Rational Design of Daunorubicin C-14 Hydroxylase Based on the Understanding of Its Substrate-Binding Mechanism
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24098337
Abstract: Doxorubicin is one of the most widely used antitumor drugs and is currently produced via the chemical conversion method, which suffers from high production costs, complex product separation processes, and serious environmental pollution. Biocatalysis is… read more here.
Keywords: daunorubicin; substrate binding; doxa; daunorubicin hydroxylase ... See more keywords
Performance of Pristine versus Magnetized Orange Peels Biochar Adapted to Adsorptive Removal of Daunorubicin: Eco-Structuring, Kinetics and Equilibrium Studies
Sign Up to like & getrecommendations! Published in 2023 at "Nanomaterials"
DOI: 10.3390/nano13091444
Abstract: Drugs and pharmaceuticals are an emergent class of aquatic contaminants. The existence of these pollutants in aquatic bodies is currently raising escalating concerns because of their negative impact on the ecosystem. This study investigated the… read more here.
Keywords: mag opbc; peels biochar; daunorubicin; orange peels ... See more keywords
Daunorubicin and Its Active Metabolite Pharmacokinetic Profiles in Acute Myeloid Leukaemia Patients: A Pharmacokinetic Ancillary Study of the BIG-1 Trial
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14040792
Abstract: Daunorubicin pharmacokinetics (PK) are characterised by an important inter-individual variability, which raises questions about the optimal dose regimen in patients with acute myeloid leukaemia. The aim of the study is to assess the joint daunorubicin/daunorubicinol… read more here.
Keywords: ancillary study; daunorubicin; daunorubicin daunorubicinol; acute myeloid ... See more keywords