Fertility and early embryonic development toxicity and toxicokinetic study of KFP‐H008 in Sprague–Dawley rats
Sign Up to like & getrecommendations! Published in 2022 at "Birth Defects Research"
DOI: 10.1002/bdr2.2002
Abstract: The novel potassium competitive acid blocker, KFP‐H008, developed to overcome the shortcomings of proton pump inhibitors. In this study, KFP‐H008 was administered by oral gavage at doses of 0 (control), 15, 45, and 150 mg/kg to… read more here.
Keywords: sprague dawley; dawley rats; toxicokinetic study; study kfp ... See more keywords
Bilateral Olfactory Mucosa Damage Induces the Disappearance of Olfactory Glomerulus and Reduces the Expression of Extrasynaptic α5GABAARs in the Hippocampus in Early Postnatal Sprague Dawley Rats
Sign Up to like & getrecommendations! Published in 2018 at "Neurotoxicity Research"
DOI: 10.1007/s12640-018-9893-3
Abstract: Chloroform-induced olfactory mucosal degeneration has been reported in adult rats following gavage. We used fixed-point chloroform infusions on different postnatal days (PNDs) to investigate the effects of early olfactory bilateral deprivation on the main olfactory… read more here.
Keywords: olfactory; disappearance; dawley rats; chloroform ... See more keywords
High-fructose diet initiated during adolescence does not affect basolateral amygdala excitability or affective-like behavior in Sprague Dawley rats
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2019.02.042
Abstract: &NA; Patients with type‐2 diabetes, obesity, and metabolic syndrome have a significantly increased risk of developing depression. Dysregulated metabolism may contribute to the etiology of depression by affecting neuronal activity in key limbic areas. The… read more here.
Keywords: like behavior; sprague dawley; dawley rats; excitability ... See more keywords
High-dose etoposide formulations do not saturate intestinal P-glycoprotein: Development, stability, and pharmacokinetics in Sprague-Dawley rats.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119399
Abstract: It has been suggested that oral absorption of low-permeable P-glycoprotein (P-gp) substrates can be increased through saturation of P-gp. For BCS class IV drug substances, saturating P-gp is challenging due to low aqueous solubility. The… read more here.
Keywords: dawley rats; formulation; solubility; glycoprotein ... See more keywords
Knockout of latrophilin-3 in Sprague-Dawley rats causes hyperactivity, hyper-reactivity, under-response to amphetamine, and disrupted dopamine markers
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2019.104494
Abstract: Attention deficit hyperactivity disorder is a pervasive developmental disorder characterized by inattention, impulsivity, and hyperactivity and is 75-90% heritable. Latrophilin-3 (LPHN3; or ADGRL(3)) is associated with a subtype of ADHD, but how it translates to… read more here.
Keywords: response; hyperactivity; dopamine markers; dawley rats ... See more keywords
Monosodium glutamate exposure during the neonatal period leads to cognitive deficits in adult Sprague-Dawley rats
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2018.06.008
Abstract: Epidemiological surveys show that 70-80% of patients with Alzheimer's disease (AD) have type 2 diabetes mellitus (T2DM) or show an abnormality of blood glucose levels. Therefore, an increasing number of evidence has suggested that diabetic… read more here.
Keywords: monosodium glutamate; sprague dawley; dawley rats; neonatal period ... See more keywords
Comment on "Transcript profiling in the testes and prostates of postnatal day 30 Sprague-Dawley rats exposed prenatally and lactationally to 2-hydroxy-4-methoxybenzophenone".
Sign Up to like & getrecommendations! Published in 2018 at "Reproductive Toxicology"
DOI: 10.1016/j.reprotox.2018.10.001
Abstract: Abstract 2-hydroxy-4-methoxybenzophenone (HMB) is an ultraviolet light-absorbing compound that is used in sunscreens, cosmetics and plastics. HMB has been reported to have weak estrogenic activity by in vivo and in vitro studies, making it a… read more here.
Keywords: hydroxy methoxybenzophenone; postnatal day; dawley rats; day ... See more keywords
A two-generation reproductive toxicity study of sodium molybdate dihydrate administered in drinking water or diet to Sprague-Dawley rats.
Sign Up to like & getrecommendations! Published in 2019 at "Reproductive toxicology"
DOI: 10.1016/j.reprotox.2018.11.004
Abstract: In an OECD Test Guideline 416 multigenerational study, groups of 24 male and 24 female Sprague-Dawley rats were administered sodium molybdate dihydrate at 0, 5, 17, or 40 mg molybdenum (Mo)/kg bw/day in the drinking water… read more here.
Keywords: water; dawley rats; toxicity; day ... See more keywords
Incidence of spontaneous arrhythmias in freely moving healthy untreated Sprague-Dawley rats.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmacological and toxicological methods"
DOI: 10.1016/j.vascn.2019.106589
Abstract: Spontaneous arrhythmia characterization in healthy rats can support interpretation when studying novel therapies. Male (n = 55) and female (n = 40) Sprague-Dawley rats with telemetry transmitters for a derivation II ECG. Arrhythmias were assessed from continuous ECG monitoring… read more here.
Keywords: incidence spontaneous; spontaneous arrhythmias; sprague dawley; dawley rats ... See more keywords
Impact of extensive plasma protein binding on the in situ hepatic uptake and clearance of perampanel and fluoxetine in Sprague Dawley rats.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2020.07.003
Abstract: The main objective was to investigate the effect of albumin (ALB) and/or alpha-1-acid glycoprotein (AGP) on the hepatic clearance (CLh) of the drugs that bind, extensively, to both proteins. Isolated perfused livers from male Sprague… read more here.
Keywords: plasma; dawley rats; clearance; hepatic uptake ... See more keywords
Effects of Bisphenol A and Bisphenol S Exposure at Low Doses on the Metabolome of Adolescent Male Sprague-Dawley Rats.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.1c00018
Abstract: Toxic effects induced upon exposure to low-dose bisphenol A (BPA) or bisphenol S (BPS) remains controversial. In this study, metabolomics was used to examine the metabolomic perturbation arising from 28 days of exposure to BPA… read more here.
Keywords: regulation metabolites; dawley rats; exposure; bps ... See more keywords