Prognostic significance of Daxx NCR (Nuclear/Cytoplasmic Ratio) in gastric cancer
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Medicine"
DOI: 10.1002/cam4.1144
Abstract: In addition to regulating apoptosis via its interaction with the death domain of Fas receptor, death domain associated protein 6 (Daxx) is also known to be involved in transcriptional regulation, suggesting that the function of… read more here.
Keywords: risk; daxx; nuclear cytoplasmic; ratio ... See more keywords
Rapid and reversible suppression of ALT by DAXX in osteosarcoma cells
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-41058-8
Abstract: Many tumors maintain chromosome-ends through a telomerase-independent, DNA-templated mechanism called alternative lengthening of telomeres (ALT). While ALT occurs in only a subset of tumors, it is strongly associated with mutations in the genes ATRX and… read more here.
Keywords: daxx; rapid reversible; atrx daxx; osteosarcoma ... See more keywords
Histone H3F3/H3.3 chaperone DAXX converts to modulate SQSTM1 phase condensation for NFE2L2 activation
Sign Up to like & getrecommendations! Published in 2019 at "Autophagy"
DOI: 10.1080/15548627.2019.1677323
Abstract: ABSTRACT Macroautophagy/autophagy cargo receptor SQSTM1/p62 puncta or clustering formation is critical for its function in cargo recognition and LC3 interaction. Evidence suggests that SQSTM1 puncta formation is a process of liquid-liquid phase separation. It is… read more here.
Keywords: phase; daxx; liquid; sqstm1 phase ... See more keywords
Performance of DAXX Immunohistochemistry as a Screen for DAXX Mutations in Pancreatic Neuroendocrine Tumors
Sign Up to like & getrecommendations! Published in 2019 at "Pancreas"
DOI: 10.1097/mpa.0000000000001256
Abstract: Objectives DAXX immunohistochemistry (IHC) is often used as a surrogate for sequencing. We aimed to elucidate the sensitivity of IHC for DAXX mutation. Methods All pancreatic neuroendocrine tumors (PanNETs) with DAXX mutations detected by sequencing… read more here.
Keywords: expression; daxx immunohistochemistry; daxx; neuroendocrine tumors ... See more keywords
Daxx maintains endogenous retroviral silencing and restricts cellular plasticity in vivo
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.aba8415
Abstract: Daxx loss causes coordinate dysregulation of ERVs and protein-coding genes after physiologic stress and impairs tissue recovery. Tumor sequencing studies have emphasized the role of epigenetics and altered chromatin homeostasis in cancer. Mutations in DAXX,… read more here.
Keywords: maintains endogenous; daxx; daxx maintains; silencing restricts ... See more keywords
Abstract 1466: DAXX localizes ATRX to suppress alternative lengthening of telomeres in osteosarcoma
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-1466
Abstract: To maintain genome stability, proliferating cells must add telomere sequence to counteract the chromosome end replication problem. In normal cells, telomeres are lengthened through the action of the enzyme telomerase. In about 10-15% of tumors,… read more here.
Keywords: daxx localizes; daxx; alternative lengthening; localizes atrx ... See more keywords
ATRX/DAXX: Guarding the Genome against the Hazards of ALT
Sign Up to like & getrecommendations! Published in 2023 at "Genes"
DOI: 10.3390/genes14040790
Abstract: Proliferating cells must enact a telomere maintenance mechanism to ensure genomic stability. In a subset of tumors, telomeres are maintained not by telomerase, but through a homologous recombination-based mechanism termed Alternative Lengthening of Telomeres or… read more here.
Keywords: daxx guarding; hazards alt; guarding genome; daxx ... See more keywords