Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation
Sign Up to like & getrecommendations! Published in 2021 at "Nature Cell Biology"
DOI: 10.1038/s41556-021-00774-y
Abstract: Defective silencing of retrotransposable elements has been linked to inflammageing, cancer and autoimmune diseases. However, the underlying mechanisms are only partially understood. Here we implicate the histone H3.3 chaperone Daxx, a retrotransposable element repressor inactivated… read more here.
Keywords: neutrophilia inflammation; chromatin landscape; chaperone daxx; daxx haematopoietic ... See more keywords