Specific intron-dependent loading of DAZAP1 onto the cox6c transcript suppresses pre-mRNA splicing efficacy and induces cell growth retardation.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2018.03.005
Abstract: DAZAP1 is an evolutionarily conserved RNA-binding protein expressed in many tissues in mice and humans. DAZAP1-knockout mice carrying a partial loss-of-function (hypomorphic) allele exhibited severe deficiencies in spermatogenesis and cell growth, indicating that DAZAP1 plays… read more here.
Keywords: cox6c; cell growth; mrna splicing; dazap1 ... See more keywords
DAZAP1 maintains gastric cancer stemness by inducing mitophagy
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DOI: 10.1172/jci.insight.175422
Abstract: Stem cells play a pivotal role in the malignant behavior of gastric cancer (GC), complicating its treatment and prognosis. However, the regulatory mechanisms of GC stem cells (GCSCs) remain poorly understood. DAZ-associated protein 1 (DAZAP1),… read more here.
Keywords: dazap1; stemness; gastric cancer; stem cells ... See more keywords