The RNA-binding protein DAZL functions as repressor and activator of mRNA translation during oocyte maturation
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-15209-9
Abstract: Deleted in azoospermia-like (DAZL) is an RNA-binding protein critical for gamete development. In full-grown oocytes, the DAZL protein increases 4-fold during reentry into the meiotic cell cycle. Here, we have investigated the functional significance of… read more here.
Keywords: rna binding; dazl; translation; binding protein ... See more keywords
DAZL regulates proliferation of human primordial germ cells by direct binding to precursor miRNAs and enhances DICER processing activity
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac856
Abstract: Abstract Understanding the molecular and cellular mechanisms of human primordial germ cells (hPGCs) is essential in studying infertility and germ cell tumorigenesis. Many RNA-binding proteins (RBPs) and non-coding RNAs are specifically expressed and functional during… read more here.
Keywords: cell; germ; proliferation; human primordial ... See more keywords
Requirement of the 3′-UTR-dependent suppression of DAZL in oocytes for pre-implantation mouse development
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DOI: 10.1371/journal.pgen.1007436
Abstract: Functional oocytes are produced through complex molecular and cellular processes. In particular, the contribution of post-transcriptional gene regulation mediated by RNA-binding proteins (RBPs) is crucial for controlling proper gene expression during this process. DAZL (deleted… read more here.
Keywords: dazl; development; suppression dazl; pre implantation ... See more keywords
DAZL mediates a broad translational program regulating expansion and differentiation of spermatogonial progenitors
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.56523
Abstract: Fertility across metazoa requires the germline-specific DAZ family of RNA-binding proteins. Here we examine whether DAZL directly regulates progenitor spermatogonia using a conditional genetic mouse model and in vivo biochemical approaches combined with chemical synchronization… read more here.
Keywords: dazl; differentiation; differentiation spermatogonial; expansion differentiation ... See more keywords