DBC1 is a key positive regulator of enhancer epigenomic writers KMT2D and p300
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac585
Abstract: Abstract Histone modification is a key epigenetic mechanism for regulation of chromatin dynamics and gene expression. Deleted in breast cancer 1 (DBC1) has been shown to act as a negative regulator of epigenetic modifiers and… read more here.
Keywords: dbc1; kmt2d p300; positive regulator; enhancer ... See more keywords
DBC1, Deleted in Breast Cancer 1, Is a Nuclear STAT5A-Interacting Protein in Adipocytes, but Its Primary Effects on GLUT4 Gene Expression and Lipolysis Are STAT5 Independent
Sign Up to like & getrecommendations! Published in 2018 at "Diabetes"
DOI: 10.2337/db18-1761-p
Abstract: STAT5A (signal transducer and activator of transcription 5A) is a transcription factor that plays a role in adipocyte development and function. Although the role of STAT5A in fat cell development is well characterized, its specific… read more here.
Keywords: dbc1; stat5a; lipolysis; expression ... See more keywords
Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.81247
Abstract: DBC1 has been characterized as a key regulator of physiological and pathophysiological activities, such as DNA damage, senescence, and tumorigenesis. However, the mechanism by which the functional stability of DBC1 is regulated has yet to… read more here.
Keywords: progression; degradation dbc1; dbc1; breast cancer ... See more keywords