Abstract 4972: Novel Ras inhibitor DC070-547 potently and selectively blocks Ras-RBD binding, EGFR binding to Ras signaling complex, EGFR activation of Ras signaling, and growth of Ras-driven lung tumor cells
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DOI: 10.1158/1538-7445.am2017-4972
Abstract: A novel series of compounds that potently and selectively inhibits the growth of tumor cells harboring constitutively activated Ras relative to cells lacking activated Ras were identified by screening a proprietary library of indene derivatives… read more here.
Keywords: egfr; dc070 547; tumor cells; ras signaling ... See more keywords
Abstract 5159: Characterization of a novel class of RAS inhibitory compounds with potent anti-tumor activity
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DOI: 10.1158/1538-7445.am2017-5159
Abstract: Introduction: Over 30% of all human cancers harbor activating RAS mutations which induce deregulation of the cell cycle, uncontrolled proliferation, and decreased apoptosis. Through a phenotypic screening strategy, we have identified a series of indene… read more here.
Keywords: growth; dc070 547; activated ras; cell ... See more keywords