Astrocyte‐selective STAT3 knockdown rescues methamphetamine withdrawal‐disrupted spatial memory in mice via restoring the astrocytic capacity of glutamate clearance in dCA1
Sign Up to like & getrecommendations! Published in 2021 at "Glia"
DOI: 10.1002/glia.24046
Abstract: Methamphetamine (METH) is a common abused drug. METH‐triggered glutamate (Glu) levels in dorsal CA1 (dCA1) could partially explain the etiology of METH‐caused abnormal memory, but the synaptic mechanism remains unclear. Here, we found that METH… read more here.
Keywords: capacity; glu; clearance; withdrawal ... See more keywords
Phosphorylation of PSD-95 at serine 73 in dCA1 is required for extinction of contextual fear
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DOI: 10.1371/journal.pbio.3002106
Abstract: The updating of contextual memories is essential for survival in a changing environment. Accumulating data indicate that the dorsal CA1 area (dCA1) contributes to this process. However, the cellular and molecular mechanisms of contextual fear… read more here.
Keywords: contextual fear; dca1; psd serine; phosphorylation psd ... See more keywords
14-3-3 Dysfunction in Dorsal Hippocampus CA1 (dCA1) Induces Psychomotor Behavior via a dCA1-Lateral Septum-Ventral Tegmental Area Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.817227
Abstract: While hippocampal hyperactivity is implicated in psychosis by both human and animal studies, whether it induces a hyperdopaminergic state and the underlying neural circuitry remains elusive. Previous studies established that region-specific inhibition of 14-3-3 proteins… read more here.
Keywords: hippocampus ca1; ca1 dca1; dorsal hippocampus; dysfunction ... See more keywords