CRL4-DCAF8L1 Regulates BRCA1 and BARD1 Protein Stability
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DOI: 10.7150/ijbs.57178
Abstract: BRCA1 is frequently down-regulated in breast cancer, the underlying mechanism is unclear. Here we identified DCAF8L1, an X-linked gene product, as a DDB1-Cullin associated Factor (DCAF) for CUL4 E3 ligases to target BRCA1 and BARD1… read more here.
Keywords: stability; breast cancer; dcaf8l1; brca1 bard1 ... See more keywords