Transcript-specific induction of stop codon readthrough using a CRISPR-dCas13 system
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DOI: 10.1038/s44319-024-00115-8
Abstract: Stop codon readthrough (SCR) is the process where translation continues beyond a stop codon on an mRNA. Here, we describe a strategy to enhance or induce SCR in a transcript-selective manner using a CRISPR-dCas13 system.… read more here.
Keywords: dcas13 system; crispr dcas13; stop codon; dcas13 ... See more keywords
CRISPR-iPAS: a novel dCAS13-based method for alternative polyadenylation interference
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DOI: 10.1093/nar/gkac108
Abstract: Abstract Alternative polyadenylation (APA) plays an important role in gene regulation. With the recent application of novel sequencing technology in APA profiling, an ever-increasing number of APA genes/sites have been identified. However, the phenotypic relevance… read more here.
Keywords: alternative polyadenylation; dcas13; apa; interference ... See more keywords