Transcriptional activation of endogenous Oct4 via the CRISPR/dCas9 activator ameliorates Hutchinson-Gilford progeria syndrome in mice.
Sign Up to like & getrecommendations! Published in 2023 at "Aging cell"
DOI: 10.1111/acel.13825
Abstract: Partial cellular reprogramming via transient expression of Oct4, Sox2, Klf4, and c-Myc induces rejuvenation and reduces aged-cell phenotypes. In this study, we found that transcriptional activation of the endogenous Oct4 gene by using the CRISPR/dCas9… read more here.
Keywords: transcriptional activation; dcas9 activator; dcas9; crispr dcas9 ... See more keywords