Presence of the ketamine analog of 2-fluorodeschloroketamine residues in wastewater.
Sign Up to like & getrecommendations! Published in 2021 at "Drug testing and analysis"
DOI: 10.1002/dta.3098
Abstract: Ketamine (KET) analogues are increasingly emerging as new psychoactive substances (NPS). The present report describes the first detection of the KET analogue, 2-fluorodeschloroketamine (2F-DCK), in influent samples collected from nine wastewater treatment plants in seven… read more here.
Keywords: fluorodeschloroketamine; ket; ketamine analog; dck ... See more keywords
Exosomes confer chemoresistance to pancreatic cancer cells by promoting ROS detoxification and miR-155-mediated suppression of key gemcitabine-metabolising enzyme, DCK
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Cancer"
DOI: 10.1038/bjc.2017.18
Abstract: Background:Chemoresistance is a significant clinical problem in pancreatic cancer (PC) and underlying molecular mechanisms still remain to be completely understood. Here we report a novel exosome-mediated mechanism of drug-induced acquired chemoresistance in PC cells.Methods:Differential ultracentrifugation… read more here.
Keywords: chemoresistance; gem; mir 155; gemcitabine ... See more keywords
dCK negatively regulates the NRF2/ARE axis and ROS production in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cell Proliferation"
DOI: 10.1111/cpr.12456
Abstract: Decreased deoxycytidine kinase (dCK) expression is a reported indicator of gemcitabine efficacy in pancreatic cancer, due to the impact of this kinase on gemcitabine metabolism. The transcription factor NF‐E2 p45‐related factor 2 (NRF2, also called… read more here.
Keywords: dck; negatively regulates; pancreatic cancer; regulates nrf2 ... See more keywords
Targeting deoxycytidine kinase improves symptoms in mouse models of multiple sclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Immunology"
DOI: 10.1111/imm.13569
Abstract: Multiple sclerosis (MS) is an autoimmune disease driven by lymphocyte activation against myelin autoantigens in the central nervous system leading to demyelination and neurodegeneration. The deoxyribonucleoside salvage pathway with the rate‐limiting enzyme deoxycytidine kinase (dCK)… read more here.
Keywords: dck; deoxycytidine kinase; deoxyribonucleoside salvage; multiple sclerosis ... See more keywords
Targeting Oncoproteins with a Positive Selection Assay for Protein Degraders
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-141558
Abstract: Cancer genome sequencing studies have identified frequent driver mutations that alter the function of transcription factors (TFs). However, most TFs, are classically "undruggable". The discovery that IMiDs [immunomodulatory drugs e.g.Lenalidomide (LEN) and Pomalidomide (POM)] exert… read more here.
Keywords: dck ikzf1; pom; dck; spautin ... See more keywords
DCK is a promising prognostic biomarker and correlated with immune infiltrates in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "World Journal of Surgical Oncology"
DOI: 10.1186/s12957-020-01953-1
Abstract: Background Deoxycytidine kinase ( DCK ), an enzyme in the nucleoside biosynthetic pathway, can affect the development of immune cells. However, the relationships between the expression of DCK , patient prognosis, and tumor-infiltrating immune cells… read more here.
Keywords: hepatocellular carcinoma; dck expression; expression dck; dck ... See more keywords