Alternative splice variants of DCLK1 mark cancer stem cells, promote self‐renewal and drug‐resistance, and can be targeted to inhibit tumorigenesis in kidney cancer
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Cancer"
DOI: 10.1002/ijc.31400
Abstract: Renal cell carcinoma (RCC) is a common and devastating disease characterized by a hypoxic microenvironment, epithelial‐mesenchymal transition and potent resistance to therapy evidencing the presence of cancer stem cells (CSCs). Various CSC markers have been… read more here.
Keywords: rcc; self renewal; resistance; cancer ... See more keywords
DCLK1 as a Promising Marker for Radioresistance in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Gastrointestinal Cancer"
DOI: 10.1007/s12029-019-00292-z
Abstract: Colorectal cancer (CRC) is considered third in terms of frequency and second regarding of mortality, where it has been estimated, over 1.8 million new colorectal cancer cases and 881,000 deaths occurred in 2018 [1]. It… read more here.
Keywords: radioresistance; colorectal cancer; crc; cancer ... See more keywords
Chemical Biology Toolkit for DCLK1 Reveals Connection to RNA Processing.
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DOI: 10.1016/j.chembiol.2020.07.011
Abstract: Doublecortin-like kinase 1 (DCLK1) is critical for neurogenesis, but overexpression is also observed in multiple cancers and is associated with poor prognosis. Nevertheless, the function of DCLK1 in cancer, especially the context-dependent functions, are poorly… read more here.
Keywords: biology toolkit; chemical biology; rna processing; biology ... See more keywords
Inhibition of DCLK1 down-regulates PD-L1 expression through Hippo pathway in human pancreatic cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.117150
Abstract: Immunotherapy is one of the most promising strategies for cancer, compared with traditional treatments. As one of the key emerging immunotherapies, anti-PD-1/PD-L1 treatment has brought survival benefits to many advanced cancer patients. However, in pancreatic… read more here.
Keywords: pancreatic cancer; expression; hippo pathway; cancer ... See more keywords
Spatial and temporal diversity of DCLK1 isoforms in developing mouse brain
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DOI: 10.1016/j.neures.2020.12.004
Abstract: Doublecortin-like kinase 1 (DCLK1) is a Doublecortin family kinase involved in a range of brain development processes including cell migration, axon/dendrite growth, and synapse development. The Dclk1 gene potentially generates multiple splicing isoforms, but the… read more here.
Keywords: developing mouse; dclk1 isoforms; dclk1; mouse brain ... See more keywords
DCLK1 promotes tumour invasion and metastasis through epithelial-mesenchymal transition and the MEK/ERK pathway in esophageal squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdz422.053
Abstract: Abstract Background Doublecortin-like kinase1 (DCLK1), a recently discovered cancer stem cell (CSC) marker in the colon and pancreatic cancer, contributes greatly to the malignancy of gastrointestinal cancers. Also, higher DCLK1 expression is reported in esophageal… read more here.
Keywords: mek erk; escc; erk pathway; cell ... See more keywords
Targeting Doublecortin-Like Kinase 1 (DCLK1)-Regulated SARS-CoV-2 Pathogenesis in COVID-19
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00967-22
Abstract: High mortality in COVID-19 is associated with underlying comorbidities such as chronic liver diseases. Successful treatment of severe/critical COVID-19 remains challenging. ABSTRACT Host factors play critical roles in SARS-CoV-2 infection-associated pathology and the severity of… read more here.
Keywords: dclk1; dclk1 s100a9; kinase; expression ... See more keywords
DCLK1 Plays a Metastatic-Promoting Role in Human Breast Cancer Cells
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DOI: 10.1155/2019/1061979
Abstract: Background Doublecortin-like kinase 1 (DCLK1) has been universally identified as a cancer stem cell (CSC) marker and is found to be overexpressed in many types of cancers including breast cancer. However, there is little data… read more here.
Keywords: breast cancer; role; cancer cells; cancer ... See more keywords
Pancreatic Neuroendocrine Tumors and EMT Behavior Are Driven by the CSC Marker DCLK1
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DOI: 10.1158/1541-7786.mcr-16-0285
Abstract: Doublecortin-like kinase 1 (DCLK1), a marker for intestinal and pancreatic cancer stem cells, is highly expressed in neuroblastomas. This study was conducted to assess DCLK1 expression levels in pancreatic neuroendocrine tumor (PNET) tissues and to… read more here.
Keywords: pancreatic neuroendocrine; cancer; marker dclk1; marker ... See more keywords
DCLK1-Short Splice Variant Promotes Esophageal Squamous Cell Carcinoma Progression via the MAPK/ERK/MMP2 Pathway
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DOI: 10.1158/1541-7786.mcr-21-0161
Abstract: Cancer stem cell (CSC) marker doublecortin-like kinase 1 (DCLK1) contributes greatly to the malignancy of gastrointestinal cancers, and DCLK1-targeted agents have potential therapeutic value. However, the molecular pathways regulated by DCLK1-S (DCLK1 isoform 4), a… read more here.
Keywords: erk mmp2; progression; mapk erk; dclk1 ... See more keywords
Elevated doublecortin-like kinase 1 serum levels revert to baseline after therapy in early stage esophageal adenocarcinoma
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DOI: 10.1186/s40364-019-0157-z
Abstract: BackgroundBarrett’s esophagus (BE) and esophageal adenocarcinoma (EAC) incidence has been increasing in the United States for greater than 30 years. For the majority of EAC patients, treatment is limited and prognosis poor. Doublecortin like kinase-1 (DCLK1)… read more here.
Keywords: like kinase; treatment; doublecortin like; esophageal adenocarcinoma ... See more keywords