Articles with "dcn" as a keyword



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Functional organization and connectivity of the dorsal column nuclei complex reveals a sensorimotor integration and distribution hub

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Published in 2020 at "Journal of Comparative Neurology"

DOI: 10.1002/cne.24942

Abstract: The dorsal column nuclei complex (DCN‐complex) includes the dorsal column nuclei (DCN, referring to the gracile and cuneate nuclei collectively), external cuneate, X, and Z nuclei, and the median accessory nucleus. The DCN are organized… read more here.

Keywords: dcn; nuclei; sensorimotor; organization connectivity ... See more keywords

EGR3 Transcriptionally Upregulates the Expression of DCN in Liver Cancer to Inhibit Tumor Progression

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Published in 2025 at "Journal of Biochemical and Molecular Toxicology"

DOI: 10.1002/jbt.70399

Abstract: Decorin (DCN), a multifunctional extracellular matrix protein, has been reported to exhibit tumor‐suppressive effects in various cancers, including liver cancer. However, the transcriptional regulatory mechanisms of DCN in liver cancer remains unclear. We analyzed DCN… read more here.

Keywords: liver cancer; tumor; dcn liver; dcn ... See more keywords

DCN, NPM3 and SULF1 are hub genes related to vasculogenic mimicry in lung adenocarcinoma

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Published in 2025 at "Journal of Cancer Research and Clinical Oncology"

DOI: 10.1007/s00432-025-06361-0

Abstract: Vasculogenic mimicry (VM), a process in which cancer cells form endothelial cell-independent vascular networks, is a hallmark of tumor aggressiveness in lung adenocarcinoma (LUAD) and supports tumor growth and metastasis. This study aims to identify… read more here.

Keywords: dcn; lung adenocarcinoma; vasculogenic mimicry; sulf1 ... See more keywords

Fabrication of novel elastosomes for boosting the transdermal delivery of diacerein: statistical optimization, ex-vivo permeation, in-vivo skin deposition and pharmacokinetic assessment compared to oral formulation

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Published in 2018 at "Drug Delivery"

DOI: 10.1080/10717544.2018.1451572

Abstract: Abstract Diacerein (DCN) is a hydrophobic osteoarthritis (OA) drug with short half-life and low oral bioavailability. Furthermore, DCN oral administration is associated with diarrhea which represents obstacle against its oral use. Hence, this article aimed… read more here.

Keywords: transdermal delivery; vivo; dcn; drug ... See more keywords

Novel DCN Mutation in Armenian Family With Congenital Stromal Corneal Dystrophy

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Published in 2022 at "Cornea"

DOI: 10.1097/ico.0000000000003167

Abstract: Supplemental Digital Content is Available in the Text. Purpose: Congenital stromal corneal dystrophy (CSCD) is a rare congenital, dominantly inherited disorder characterized by diffuse stromal opacification associated with mutations in the decorin gene (DCN). As… read more here.

Keywords: family; cscd; congenital stromal; corneal ... See more keywords

Monoaminergic mediation of hyperalgesic and analgesic descending control of nociception in mice.

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Published in 2022 at "Pain"

DOI: 10.1097/j.pain.0000000000002806

Abstract: ABSTRACT Descending control of nociception (DCN; also known as conditioned pain modulation [CPM], the behavioral correlate of diffuse noxious inhibitory controls) is the phenomenon whereby pain inhibits pain in another part of the body and… read more here.

Keywords: hyperalgesic dcn; descending control; dcn; pain ... See more keywords

Diabetic Charcot neuroarthropathy: A threat to both limb and life

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Published in 2024 at "Diabetes"

DOI: 10.1111/dom.15994

Abstract: Diabetic Charcot neuroarthropathy (DCN), first described in 1936, occurs in less than 1% of diabetic patients, but in those diabetic subjects with distal symmetrical polyneuropathy, the overall incidence increases to 30% and the risk is… read more here.

Keywords: dcn; neuroarthropathy threat; charcot neuroarthropathy; foot ulcer ... See more keywords

Expression and secretion of SPARC, FGF-21 and DCN in bovine muscle cells: Effects of age and differentiation

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Published in 2024 at "PLOS ONE"

DOI: 10.1371/journal.pone.0299975

Abstract: Skeletal muscle growth is an economically important trait in the cattle industry. Secreted muscle-derived proteins, referred to as myokines, have important roles in regulating the growth, metabolism, and health of skeletal muscle in human and… read more here.

Keywords: sparc fgf; dcn; muscle; secretion ... See more keywords

While Urine and Plasma Decorin Remain Unchanged in Prostate Cancer, Prostatic Tissue Decorin Has a Prognostic Value.

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Published in 2020 at "Iranian biomedical journal"

DOI: 10.29252/ibj.24.4.229

Abstract: Background Numerous studies confirmed significant decrease in tissue DCN expression is associated to tumor progression and metastasis in certain types of cancer including PC. However, the potential prognostic value of tissue DCN in PC has… read more here.

Keywords: plasma; value; tissue; dcn ... See more keywords

Decorin–induced, preeclampsia-associated microRNA-512-3p restrains extravillous trophoblast functions by targeting USF2/PPP3R1 axis

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Published in 2022 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2022.1014672

Abstract: Decorin (DCN) is a leucine-rich proteoglycan produced by chorionic villus mesenchymal cells anddecidual cells during human pregnancy. Studies from our laboratory demonstrated that decidua-derived DCN restrains multiple trophoblast functions including proliferation, migration, invasion andendovascular differentiation,… read more here.

Keywords: mir 512; decorin; trophoblast functions; dcn ... See more keywords

Progranulin inhibits autophagy to facilitate intracellular colonization of Helicobacter pylori through the PGRN/mTOR/DCN axis in gastric epithelial cells

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Published in 2024 at "Frontiers in Cellular and Infection Microbiology"

DOI: 10.3389/fcimb.2024.1425367

Abstract: Helicobacter pylori (H. pylori) infection is the primary risk factor for the progress of gastric diseases. The persistent stomach colonization of H. pylori is closely associated with the development of gastritis and malignancies. Although the… read more here.

Keywords: pgrn; dcn; pylori; mtor ... See more keywords