Human DCP1 is crucial for mRNA decapping and possesses paralog-specific gene regulating functions
Sign Up to like & getrecommendations! Published in 2024 at "eLife"
DOI: 10.1101/2023.09.04.556219
Abstract: The mRNA 5’-cap structure removal by the decapping enzyme DCP2 is a critical step in gene regulation. While DCP2 is the catalytic subunit in the decapping complex, its activity is strongly enhanced by multiple factors,… read more here.
Keywords: human dcp1; dcp1a dcp1b; dcp1; mrna decapping ... See more keywords
The mRNA decapping complex is buffered by nuclear localization.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cell science"
DOI: 10.1242/jcs.259156
Abstract: mRNA decay is a key step in regulating the cellular proteome. Processing bodies (P-bodies) are thought to be sites of mRNA decay and/or storage. P-body units assemble into P-body granules under stress conditions. How this… read more here.
Keywords: nuclear localization; dcp1; decapping complex; localization ... See more keywords