Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03536-x
Abstract: The conserved decapping enzyme Dcp2 recognizes and removes the 5′ eukaryotic cap from mRNA transcripts in a critical step of many cellular RNA decay pathways. Dcp2 is a dynamic enzyme that functions in concert with… read more here.
Keywords: dcp2; dcp1 dcp2; structure; substrate ... See more keywords
Pby1 is a direct partner of the Dcp2 decapping enzyme
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa337
Abstract: Abstract Most eukaryotic mRNAs harbor a characteristic 5′ m7GpppN cap that promotes pre-mRNA splicing, mRNA nucleocytoplasmic transport and translation while also protecting mRNAs from exonucleolytic attacks. mRNA caps are eliminated by Dcp2 during mRNA decay,… read more here.
Keywords: dcp2 decapping; dcp2; pby1 direct; direct partner ... See more keywords
Decapping factor Dcp2 controls mRNA abundance and translation to adjust metabolism and filamentation to nutrient availability.
Sign Up to like & getrecommendations! Published in 2023 at "eLife"
DOI: 10.7554/elife.85545
Abstract: Degradation of most yeast mRNAs involves decapping by Dcp1/Dcp2. DEAD-box protein Dhh1 has been implicated as an activator of decapping, in coupling codon non-optimality to enhanced degradation, and as a translational repressor, but its functions… read more here.
Keywords: nutrient availability; dcp2; filamentation; abundance ... See more keywords