Targeted Degradation of mRNA Decapping Enzyme DcpS by a VHL-Recruiting PROTAC.
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DOI: 10.1021/acschembio.2c00145
Abstract: The RNA decapping scavenger protein, DcpS, has recently been identified as a dependency in acute myeloid leukemia (AML). The potent DcpS inhibitor RG3039 attenuates AML cell viability, and shRNA knockdown of DcpS is also antiproliferative.… read more here.
Keywords: targeted degradation; dcps; aml cell; protac ... See more keywords