DcR3, stabilized by the RNA-binding protein IGF2BP2, promotes proliferation, invasion, and migration of trophoblast cells and facilitates angiogenesis.
Sign Up to like & getrecommendations! Published in 2025 at "BMC pregnancy and childbirth"
DOI: 10.1186/s12884-025-08521-z
Abstract: Preeclampsia, a pregnancy-related disorder, has high morbidity and mortality rates. Decoy receptor 3 (DcR3) plays a critical role in immune modulation during pregnancy. This study investigated the functional role of DcR3 in trophoblast cell phenotypes.… read more here.
Keywords: trophoblast cells; migration; tube formation; invasion ... See more keywords
Amelioration of amyloid-β-induced deficits by DcR3 in an Alzheimer’s disease model
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurodegeneration"
DOI: 10.1186/s13024-017-0173-0
Abstract: BackgroundMicroglia mediate amyloid-beta peptide (Aβ)-induced neuroinflammation, which is one of the key events in the pathogenesis of Alzheimer’s disease (AD). Decoy receptor 3 (DcR3)/TNFRSF6B is a pleiotropic immunomodulator that promotes macrophage differentiation toward the M2… read more here.
Keywords: amelioration amyloid; alzheimer disease; app; dcr3 ... See more keywords
Decoy Receptor 3 Inhibits Monosodium Urate-Induced NLRP3 Inflammasome Activation via Reduction of Reactive Oxygen Species Production and Lysosomal Rupture
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.638676
Abstract: Gout is a common inflammatory arthritis caused by the deposition of monosodium urate (MSU) crystals in the joints. This activates the macrophages into a proinflammatory state by inducing NLRP3-dependent interleukin-1β (IL-1β) secretion, resulting in neutrophil… read more here.
Keywords: inflammasome activation; dcr3; activation; nlrp3 inflammasome ... See more keywords
Decoy Receptor 3 Suppresses T-Cell Priming and Promotes Apoptosis of Effector T-Cells in Acute Cell-Mediated Rejection: The Role of Reverse Signaling
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.879648
Abstract: Background Decoy receptor 3 (DcR3) belongs to the tumor necrosis factor (TNF) receptor superfamily and neutralizes TNF ligands, including FasL and TRAIL, to prevent T activation during T-cell priming. However, the cellular mechanisms underlying acute… read more here.
Keywords: cell; dcr3; acute cell; cell priming ... See more keywords
Anti-apoptosis Effect of Decoy Receptor 3 in Cholangiocarcinoma Cell Line TFK-1
Sign Up to like & getrecommendations! Published in 2018 at "Chinese Medical Journal"
DOI: 10.4103/0366-6999.221271
Abstract: Background: Decoy receptor 3 (DcR3) is a protein with anti-apoptotic effect that belongs to the tumor necrosis factor receptor superfamily. DcR3 is highly expressed in a variety of malignant tumors including cholangiocarcinoma and its expression… read more here.
Keywords: cell line; cell; cholangiocarcinoma; dcr3 ... See more keywords