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   Articles with "dcx" as a keyword



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Pathogenic E2K mutation of doublecortin X (DCX) alters microtubule stabilisation and actin filament association.

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recommendations! Published in 2019 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2019.04.005

Abstract: Mutations of the microtubule (MT)-associated protein Doublecortin X (DCX) gene disrupt cortical layering in brain development. Whilst many of these pathogenic DCX mutations are within the doublecortin domains (DC1 and DC2) that mediate direct DCX-MT… read more here.

Keywords: association; dcx e2k; dcx; doublecortin dcx ... See more keywords
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Chronic tinnitus and unipolar brush cell alterations in the cerebellum and dorsal cochlear nucleus

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recommendations! Published in 2017 at "Hearing Research"

DOI: 10.1016/j.heares.2017.04.016

Abstract: Abstract Animal model research has shown that the central features of tinnitus, the perception of sound without an acoustic correlate, include elevated spontaneous and stimulus‐driven activity, enhanced burst‐mode firing, decreased variance of inter‐spike intervals, and… read more here.

Keywords: cochlear nucleus; chronic tinnitus; dcx; tinnitus ... See more keywords
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An in vitro model of lissencephaly: expanding the role of DCX during neurogenesis

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recommendations! Published in 2017 at "Molecular Psychiatry"

DOI: 10.1038/mp.2017.175

Abstract: Lissencephaly comprises a spectrum of brain malformations due to impaired neuronal migration in the developing cerebral cortex. Classical lissencephaly is characterized by smooth cerebral surface and cortical thickening that result in seizures, severe neurological impairment… read more here.

Keywords: vitro model; lissencephaly; disease; dcx ... See more keywords
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Fenofibrate impairs pro-tumorigenic potential of cancer stem cell-like cells within drug-resistant prostate cancer cell populations

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recommendations! Published in 2019 at "Annals of Oncology"

DOI: 10.1093/annonc/mdz268.074

Abstract: Abstract Background Multipotent cancer stem cells (CSC) are involved in micro-evolutionary tumor adaptation to therapeutic regimens. Due to their drug-resistance, they represent a promising target for treatment strategies of advanced prostate tumors. Fenofibrate (FF) has… read more here.

Keywords: cancer stem; prostate cancer; drug; dcx ... See more keywords
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Early born neurons are abnormally positioned in the doublecortin knockout hippocampus

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recommendations! Published in 2017 at "Human Molecular Genetics"

DOI: 10.1093/hmg/ddw370

Abstract: Human doublecortin (DCX) mutations are associated with severe brain malformations leading to aberrant neuron positioning (heterotopia), intellectual disability and epilepsy. The Dcx protein plays a key role in neuronal migration, and hippocampal pyramidal neurons in… read more here.

Keywords: early born; doublecortin; dcx; gene expression ... See more keywords
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Doublecortin and JIP3 are neural-specific counteracting regulators of dynein-mediated retrograde trafficking

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recommendations! Published in 2022 at "eLife"

DOI: 10.1101/2022.08.10.503449

Abstract: Mutations in the microtubule (MT)-binding protein doublecortin (DCX) or in the MT- based molecular motor dynein result in lissencephaly. However, a functional link between DCX and dynein has not been defined. Here, we demonstrate that… read more here.

Keywords: doublecortin; dcx; jip3; dynein mediated ... See more keywords
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A Bidirectional Symmetrical C4LC-DCX Resonant Converter With Power Limitation Capability

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recommendations! Published in 2022 at "IEEE Journal of Emerging and Selected Topics in Power Electronics"

DOI: 10.1109/jestpe.2021.3099476

Abstract: To achieve the maximum efficiency of resonant converter under wide voltage conversion gain range, two stage conversion, which adopts the resonant converter operating at resonant frequency to work as a dc–dc transformer (DCX) in isolation… read more here.

Keywords: converter; dcx; power; resonant converter ... See more keywords
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Front-End Bidirectional Symmetric Bipolar Outputs LLC DC-Transformer (DCX) for a Half Bridge Class-D Audio Amplifier

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recommendations! Published in 2021 at "IEEE Transactions on Industrial Electronics"

DOI: 10.1109/tie.2020.3038071

Abstract: A front-end bidirectional symmetric bipolar outputs (SBOs) LLC dc-transformer (DCX) for half bridge class-D audio amplifier (HB-CDAA) system is proposed and studied in this article. The bidirectional SBO LLC DCX provides SBOs for the HB-CDAA… read more here.

Keywords: llc italic; italic llc; dcx; front end ... See more keywords

A Family of DC Transformer (DCX) Topologies Based on New ZVZCS Cells With DC Resonant Capacitance

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recommendations! Published in 2017 at "IEEE Transactions on Power Electronics"

DOI: 10.1109/tpel.2016.2572146

Abstract: The series resonant soft-switching topology is widely used in high-density DCX products due to its zero switching loss. But, the conventional series resonant converter is a dual end topology, which results in complex circuit structure… read more here.

Keywords: resonant; zvzcs; topologies based; topology ... See more keywords
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An LLC-DAB Bidirectional DCX Converter With Wide Load Range ZVS and Reduced Switch Count

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recommendations! Published in 2022 at "IEEE Transactions on Power Electronics"

DOI: 10.1109/tpel.2021.3105828

Abstract: An LLC dual active bridge (DAB) bidirectional converter with reduced switch count as a dc–dc transformer (DCX) is proposed in this article. It can achieve voltage regulation, full load range zero voltage switching (ZVS) for… read more here.

Keywords: converter; dcx; load range; power ... See more keywords
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Novel lissencephaly‐associated DCX variants in the C‐terminal DCX domain affect microtubule binding and dynamics

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recommendations! Published in 2022 at "Epilepsia"

DOI: 10.1111/epi.17198

Abstract: Pathogenic variants in DCX on the X chromosome lead to lissencephaly and subcortical band heterotopia (SBH), brain malformations caused by neuronal migration defects. Its product doublecortin (DCX) binds to microtubules to modulate microtubule polymerization. How… read more here.

Keywords: variants terminal; novel lissencephaly; dcx; associated dcx ... See more keywords