Pharmacological activation of dimethylarginine dimethylaminohydrolase (DDAH) activity by inorganic nitrate and DDAH inhibition by NG-hydroxy-l-arginine, Nω,Nω-dimethyl-l-citrulline and Nω,Nω-dimethyl-Nδ-hydroxy-l-citrulline: results and overview
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DOI: 10.1007/s00726-018-2684-6
Abstract: Asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) are endogenous inhibitors of nitric oxide (NO) synthase. SDMA is excreted in the urine without major metabolization. About 10% of daily produced ADMA are excreted unchanged in the… read more here.
Keywords: dimethylarginine; dimethyl; ddah activity; citrulline ... See more keywords
Assessment of the direct effects of DDAH I on tumour angiogenesis in vivo
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DOI: 10.1007/s10456-018-9617-6
Abstract: Nitric oxide (NO) has been strongly implicated in glioma progression and angiogenesis. The endogenous inhibitors of NO synthesis, asymmetric dimethylarginine (ADMA) and N-monomethyl-l-arginine (l-NMMA), are metabolized by dimethylarginine dimethylaminohydrolase (DDAH), and hence, DDAH is an… read more here.
Keywords: absence doxycycline; assessment direct; direct effects; angiogenesis ... See more keywords
DDAH-1, via regulation of ADMA levels, protects against ischemia-induced blood-brain barrier leakage
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DOI: 10.1038/s41374-021-00541-5
Abstract: Dimethylarginine dimethylamino hydrolase-1 (DDAH-1) is an important regulator of nitric oxide (NO) metabolism that has been implicated in the pathogenesis of cardiovascular diseases. Nevertheless, its role in cerebral ischemia still needs to be elucidated. Herein,… read more here.
Keywords: blood brain; adma; ischemia; brain barrier ... See more keywords
DDAH-2 alleviates contrast medium iopromide-induced acute kidney injury through nitric oxide synthase.
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DOI: 10.1042/cs20190455
Abstract: BACKGROUND Contrast-induced acute kidney injury (CI-AKI) is one of the most common causes of hospital-acquired acute renal failure. However, the pathogenesis of CI-AKI remains unclear. Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide synthase (NOS)… read more here.
Keywords: induced acute; ddah; injury; contrast medium ... See more keywords