DDAH1 mediates gastric cancer cell invasion and metastasis via Wnt/β‐catenin signaling pathway
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12089
Abstract: Gastric cancer (GC) represents the fourth most common malignant neoplasm and the second leading cause of cancer death. Despite therapeutic advances in recent decades, the clinical outcome remains dismal owing to the fact that most… read more here.
Keywords: ddah1; invasion; gastric cancer; catenin ... See more keywords
Cardiomyocyte dimethylarginine dimethylaminohydrolase-1 (DDAH1) plays an important role in attenuating ventricular hypertrophy and dysfunction
Sign Up to like & getrecommendations! Published in 2017 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-017-0644-z
Abstract: Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthases that limits nitric oxide bioavailability. Dimethylarginine dimethylaminohydrolase-1 (DDAH1) exerts a critical role for ADMA degradation and plays an important role in NO signaling. In… read more here.
Keywords: plays important; dimethylarginine; ddah1; important role ... See more keywords
S141 A novel dimethylarginine dimethylaminohydrolase 1 (DDAH1) genetic variant associated with lower asymmetric dimethylarginine (ADMA) levels predicts accelerated lung function decline and mortality in idiopathic pulmonary fibrosis
Sign Up to like & getrecommendations! Published in 2018 at "Thorax"
DOI: 10.1136/thorax-2018-212555.147
Abstract: Background Increased nitric oxide (NO) and its generating enzyme, inducible nitric oxide synthase (iNOS), are observed in experimental models of idiopathic pulmonary fibrosis (IPF). Asymmetric dimethylarginine (ADMA) competitively inhibits iNOS and is hydrolysed by dimethylarginine… read more here.
Keywords: dimethylarginine; fibrosis; ddah1; decline ... See more keywords
DDAH1/ADMA Regulates Adiponectin Resistance in Cerebral Ischemia via the ROS/FOXO1/APR1 Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/2350857
Abstract: Dimethylarginine dimethylaminohydrolase 1 (DDAH1) protects against cerebral ischemia injury via regulating the level of asymmetric dimethylarginine (ADMA). This study is aimed at exploring the effect of adiponectin resistance on ADMA-induced neuronal loss in ischemic stroke… read more here.
Keywords: cerebral ischemia; adiponectin resistance; adma; ddah1 ... See more keywords
HMGA1 promotes the progression of lung adenocarcinoma through the STAT1-mediated transcriptional activation of DDAH1
Sign Up to like & getrecommendations! Published in 2025 at "Biology Direct"
DOI: 10.1186/s13062-025-00688-x
Abstract: Advancements in precision oncology have generated increased interest in the prognostic and therapeutic capabilities of transcription factors, among which HMGA1 is significantly correlated with LUAD prognosis. However, our understanding of HMGA1 remains insufficient. This study… read more here.
Keywords: hmga1; stat1; ddah1; hmga1 promotes ... See more keywords
Circ_0004771 Accelerates Cell Carcinogenic Phenotypes via Suppressing miR-1253-Mediated DDAH1 Inhibition in Breast Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Management and Research"
DOI: 10.2147/cmar.s273783
Abstract: Background Circ_0004771 was demonstrated to mediate cell growth promotion and apoptosis suppression in breast cancer (BC). Herein, the precise functions and mechanism of circ_0004771 in the biological property of BC cells were investigated. Methods The… read more here.
Keywords: breast cancer; ddah1; mir 1253; circ 0004771 ... See more keywords
DDAH1 Protects against Acetaminophen-Induced Liver Hepatoxicity in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11050880
Abstract: In many developed countries, acetaminophen (APAP) overdose-induced acute liver injury is a significant therapeutic problem. Dimethylarginine dimethylaminohydrolase 1 (DDAH1) is a critical enzyme for asymmetric dimethylarginine (ADMA) metabolism. Growing evidence suggests that liver dysfunction is… read more here.
Keywords: apap; liver injury; induced liver; mice ... See more keywords
Assessment of DDAH1 and DDAH2 Contributions to Psychiatric Disorders via In Silico Methods
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911902
Abstract: The contribution of nitric oxide synthases (NOSs) to the pathophysiology of several neuropsychiatric disorders is recognized, but the role of their regulators, dimethylarginine dimethylaminohydrolases (DDAHs), is less understood. This study’s objective was to estimate DDAH1… read more here.
Keywords: psychiatric disorders; ddah1 ddah2; expression; assessment ddah1 ... See more keywords