An Integrated Paediatric Population PK/PD Analysis of dDAVP: How do PK Differences Translate to Clinical Outcomes?
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacokinetics"
DOI: 10.1007/s40262-019-00798-6
Abstract: Introduction The bioequivalence of two formulations of desmopressin (dDAVP), a vasopressin analogue prescribed for nocturnal enuresis treatment in children, has been previously confirmed in adults but not in children. In this study, we aimed to… read more here.
Keywords: integrated paediatric; study; paediatric population; two formulations ... See more keywords
Desmopressin acetate use in von Willebrand's disease: a survey on current practices in Brazil.
Sign Up to like & getrecommendations! Published in 2020 at "Hematology, transfusion and cell therapy"
DOI: 10.1016/j.htct.2019.12.004
Abstract: INTRODUCTION von Willebrand's disease (VWD) is the most common inherited bleeding disorder. The 1-desamino-8-d-arginine vasopressin (DDAVP) is the treatment of choice for most responsive patients with VWD. The aim of this study was to evaluate… read more here.
Keywords: use; hematology; von willebrand; ddavp ... See more keywords
Evaluation of recombinant factor VIIa, tranexamic acid and desmopressin to reduce prasugrel-related bleeding: A randomised, placebo-controlled study in a rabbit model
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Anaesthesiology"
DOI: 10.1097/eja.0000000000000775
Abstract: BACKGROUND Prasugrel is a thienopyridine that inhibits platelet aggregation more rapidly and effectively than clopidogrel, with an increased bleeding risk. OBJECTIVE The current study aimed to evaluate the efficacy of three nonspecific haemostatic drugs –… read more here.
Keywords: prasugrel; tranexamic acid; study; placebo ... See more keywords
Uncovering the functional role of GPR39 in the renal collecting duct
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5794821
Abstract: G protein-coupled receptors (GPCRs) are seven transmembrane domain receptors that comprise the largest class of proteins in the mammalian genome. GPR39 is part of the ghrelin subfamily of GPCRs, and is well-expressed in the kidney… read more here.
Keywords: collecting duct; expression; physiology; gpr39 ... See more keywords
SAT-233 Management of Pregestational Diabetes Insipidus in Pregnancy
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-sat-233
Abstract: Abstract Introduction: The incidence of diabetes insipidus (DI) in pregnancy is rare, affecting 2 to 4 cases per 100,000 gestations. Management of pregestational DI poses a challenge for patients who are already on 1-deamino-8-D-arginine vasopressin… read more here.
Keywords: management pregestational; case; weeks gestation; pregnancy ... See more keywords
SUN-410 Central Diabetes Insipidus Refractory to Oral Desmopressin (DDAVP)
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-sun-410
Abstract: Abstract Background We report a case of CDI due to craniopharyngioma resection that became refractory to oral DDAVP after recurrence of tumor and subsequent surgical removal. Due to inability of patient to use the intranasal… read more here.
Keywords: patient; dose; mcg; day ... See more keywords
Desmopressin administration and rebleeding in subarachnoid hemorrhage: analysis of an observational prospective database.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of neurosurgery"
DOI: 10.3171/2017.7.jns17990
Abstract: OBJECTIVERebleeding remains a frequent and catastrophic event leading to poor outcome after subarachnoid hemorrhage (SAH). Reduced platelet function after the initial bleed is associated with higher risk of early rebleeding. Desmopressin (DDAVP) is a well-known… read more here.
Keywords: administration; subarachnoid hemorrhage; patients sah; desmopressin ... See more keywords
Genome-Engineered mpkCCDc14 Cells as a New Resource for Studying AQP2
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24021684
Abstract: mpkCCDc14 cells, a polarized epithelial cell line derived from mouse kidney cortical collecting ducts, are known to express the vasopressin V2 receptor (V2R) and aquaporin-2 (AQP2) that are responsive to vasopressin. However, a low abundance… read more here.
Keywords: v2r aqp2; aqp2; genome; ddavp ... See more keywords