Sirtuin 7-dependent deacetylation of DDB1 regulates the expression of nuclear receptor TR4.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.06.057
Abstract: Sirtuin 7 (SIRT7) is an NAD+-dependent deacetylase/deacylase, but only a limited number of SIRT7 substrates have been identified. Recently, we found that Sirt7 knockout mice are resistant to high-fat diet-induced fatty liver, and that SIRT7… read more here.
Keywords: ddb1; deacetylation; tr4; nuclear receptor ... See more keywords
DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109281
Abstract: Obesity has become a global pandemic. Identification of key factors in adipogenesis helps to tackle obesity and related metabolic diseases. Here, we show that DDB1 binds the histone reader BRWD3 to promote adipogenesis and diet-induced… read more here.
Keywords: ddb1; brwd3; transcriptional cascade; obesity ... See more keywords
Disruption of HBx-DDB1 by NTZ: New Mechanistic Insight Into an Old Drug With Broad Anti-infective Activities
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2018.10.013
Abstract: epatitis B virus (HBV) infection leads to chronic Hhepatitis B (CHB) in approximately 250 million people worldwide, putting them at high risk for developing cirrhosis and hepatocellular carcinoma. HBV is a partially double-stranded DNA virus… read more here.
Keywords: hbx ddb1; ddb1; hbv; disruption hbx ... See more keywords
Targeted Protein Degradation through Recruitment of the CUL4 Complex Adaptor Protein DDB1.
Sign Up to like & getrecommendations! Published in 2024 at "ACS chemical biology"
DOI: 10.1021/acschembio.3c00487
Abstract: Targeted protein degradation has arisen as a powerful therapeutic modality for eliminating proteins. Thus far, most heterobifunctional proteolysis targeting chimeras (PROTACs) have utilized recruiters against substrate receptors of Cullin RING E3 ubiquitin ligases, such as… read more here.
Keywords: adaptor protein; degradation; protein degradation; ddb1 ... See more keywords
Targeted Histone Deacetylase Degradation via Chemical Induced Proximity by Direct Recruitment of the CUL4 Complex Adaptor Protein DDB1.
Sign Up to like & getrecommendations! Published in 2025 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.5c00506
Abstract: Targeted protein degradation using proteolysis-targeting chimeras (PROTACs) has emerged as a powerful strategy for disease treatment. By recruiting E3 ligases, these molecules enable selective degradation of pathogenic proteins. Cereblon (CRBN), a key component of the… read more here.
Keywords: deacetylase degradation; degradation; cul4; targeted histone ... See more keywords
Structural insights into DDA1 function as a core component of the CRL4-DDB1 ubiquitin ligase
Sign Up to like & getrecommendations! Published in 2018 at "Cell Discovery"
DOI: 10.1038/s41421-018-0064-8
Abstract: Dear Editor, Cullin-RING ligases (CRLs) represent the largest superfamily of multi-subunit ubiquitin E3 ligases and regulate a wide range of cellular functions in all eukaryotes. As a structurally distinct sub-family of CRLs, the CRL4 E3… read more here.
Keywords: dda1; ddb1; propeller; component crl4 ... See more keywords
P049 Novel association of anti-DNA damage binding antibody (DDB-1) in idiopathic inflammatory myopathies: a case report
Sign Up to like & getrecommendations! Published in 2025 at "Rheumatology"
DOI: 10.1093/rheumatology/keaf142.091
Abstract: Idiopathic inflammatory myopathies (IIM) are a group of rare autoimmune diseases that cause muscle inflammation and can present as overlapping syndrome with other connective tissue diseases. Up to 70% of patients will have a myositis-specific… read more here.
Keywords: disease; antibody; ddb1; case ... See more keywords