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   Articles with "ddb1" as a keyword



Sirtuin 7-dependent deacetylation of DDB1 regulates the expression of nuclear receptor TR4.

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recommendations! Published in 2017 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2017.06.057

Abstract: Sirtuin 7 (SIRT7) is an NAD+-dependent deacetylase/deacylase, but only a limited number of SIRT7 substrates have been identified. Recently, we found that Sirt7 knockout mice are resistant to high-fat diet-induced fatty liver, and that SIRT7… read more here.

Keywords: ddb1; deacetylation; tr4; nuclear receptor ... See more keywords
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DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity.

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recommendations! Published in 2021 at "Cell reports"

DOI: 10.1016/j.celrep.2021.109281

Abstract: Obesity has become a global pandemic. Identification of key factors in adipogenesis helps to tackle obesity and related metabolic diseases. Here, we show that DDB1 binds the histone reader BRWD3 to promote adipogenesis and diet-induced… read more here.

Keywords: ddb1; brwd3; transcriptional cascade; obesity ... See more keywords
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Disruption of HBx-DDB1 by NTZ: New Mechanistic Insight Into an Old Drug With Broad Anti-infective Activities

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recommendations! Published in 2019 at "Cellular and Molecular Gastroenterology and Hepatology"

DOI: 10.1016/j.jcmgh.2018.10.013

Abstract: epatitis B virus (HBV) infection leads to chronic Hhepatitis B (CHB) in approximately 250 million people worldwide, putting them at high risk for developing cirrhosis and hepatocellular carcinoma. HBV is a partially double-stranded DNA virus… read more here.

Keywords: hbx ddb1; ddb1; hbv; disruption hbx ... See more keywords
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Structural insights into DDA1 function as a core component of the CRL4-DDB1 ubiquitin ligase

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recommendations! Published in 2018 at "Cell Discovery"

DOI: 10.1038/s41421-018-0064-8

Abstract: Dear Editor, Cullin-RING ligases (CRLs) represent the largest superfamily of multi-subunit ubiquitin E3 ligases and regulate a wide range of cellular functions in all eukaryotes. As a structurally distinct sub-family of CRLs, the CRL4 E3… read more here.

Keywords: dda1; ddb1; propeller; component crl4 ... See more keywords