Use of a Caco-2 permeability assay to evaluate the effects of several Kampo medicines on the drug transporter P-glycoprotein
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Natural Medicines"
DOI: 10.1007/s11418-018-1222-x
Abstract: In modern medical care in which Kampo and Western drugs are often combined, it is extremely important to clarify drug–drug interaction (DDI) to ensure safety and efficacy. However, there is little evidence of DDI in… read more here.
Keywords: five kampo; kampo medicines; drug; transporter glycoprotein ... See more keywords
Regulating the alky chain length of fatty acid-didanosine prodrugs and evaluating its role in albumin binding
Sign Up to like & getrecommendations! Published in 2017 at "Drug Delivery and Translational Research"
DOI: 10.1007/s13346-017-0428-x
Abstract: Rational design of prodrugs for efficient albumin binding shows distinct advantages in drug delivery in terms of drug availability, systemic circulation, and potential targeting effect. And fatty acids are good candidates due to their high… read more here.
Keywords: chain length; acid didanosine; ddi;
Surface amplification of pencil graphite electrode with polypyrrole and reduced graphene oxide for fabrication of a guanine/adenine DNA based electrochemical biosensors for determination of didanosine anticancer drug
Sign Up to like & getrecommendations! Published in 2018 at "Applied Surface Science"
DOI: 10.1016/j.apsusc.2018.01.237
Abstract: Abstract Didanosine is nucleoside analog reverse transcriptase inhibitors with many side effects such as nausea and vomiting, stomach pain, tingling, burning and numbness and determination of this drug is very important in biological samples. This… read more here.
Keywords: ppy rgo; rgo; pge ppy; dna ... See more keywords
Control over Phase Transformations in a Family of Flexible Double Diamondoid Coordination Networks through Linker Ligand Substitution
Sign Up to like & getrecommendations! Published in 2023 at "Chemistry of Materials"
DOI: 10.1021/acs.chemmater.3c00334
Abstract: In this work, we present the first metal–organic framework (MOF) platform with a self-penetrated double diamondoid (ddi) topology that exhibits switching between closed (nonporous) and open (porous) phases induced by exposure to gases. A crystal… read more here.
Keywords: topology; coordination; double diamondoid; ddi ... See more keywords
Update on drug interactions with non-vitamin-K-antagonist oral anticoagulants for stroke prevention in elderly patients
Sign Up to like & getrecommendations! Published in 2021 at "Expert Review of Clinical Pharmacology"
DOI: 10.1080/17512433.2021.1908124
Abstract: ABSTRACT Introduction: We update the knowledge, since the last review in 2017, about drug–drug interactions (DDI) of non-vitamin-K-antagonist oral anticoagulants (NOAC) in patients ≥75 years. Areas covered: The literature was searched for: ‘dabigatran,’ ‘rivaroxaban,’ ‘edoxaban,’… read more here.
Keywords: non vitamin; drug interactions; elderly patients; ddi ... See more keywords
R2-DDI: relation-aware feature refinement for drug-drug interaction prediction
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac576
Abstract: Precisely predicting the drug-drug interaction (DDI) is an important application and host research topic in drug discovery, especially for avoiding the adverse effect when using drug combination treatment for patients. Nowadays, machine learning and deep… read more here.
Keywords: feature refinement; drug drug; ddi; prediction ... See more keywords
IK-DDI: a novel framework based on instance position embedding and key external text for DDI extraction.
Sign Up to like & getrecommendations! Published in 2023 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbad099
Abstract: Determining drug-drug interactions (DDIs) is an important part of pharmacovigilance and has a vital impact on public health. Compared with drug trials, obtaining DDI information from scientific articles is a faster and lower cost but… read more here.
Keywords: information; extraction; framework; external text ... See more keywords
Spleen stiffness measurements using point shear wave elastography detects noncirrhotic portal hypertension in human immunodeficiency virus
Sign Up to like & getrecommendations! Published in 2019 at "Medicine"
DOI: 10.1097/md.0000000000017961
Abstract: Abstract To assess the utility of spleen stiffness as a diagnostic tool in individuals with human immunodeficiency virus (HIV) and non-cirrhotic portal hypertension (NCPH). The Philips EPIQ7, a new point shearwave elastography (pSWE) technique, was… read more here.
Keywords: spleen stiffness; portal hypertension; immunodeficiency virus; stiffness ... See more keywords
Tuning the Dipole-Dipole Interaction in a Quantum Gas with a Rotating Magnetic Field.
Sign Up to like & getrecommendations! Published in 2018 at "Physical review letters"
DOI: 10.1103/physrevlett.120.230401
Abstract: We demonstrate the tuning of the magnetic dipole-dipole interaction (DDI) within a dysprosium Bose-Einstein condensate by rapidly rotating the orientation of the atomic dipoles. The tunability of the dipolar mean-field energy manifests as a modified… read more here.
Keywords: field; gas; dipole dipole; ddi ... See more keywords
A Drug Recommendation Model Based on Message Propagation and DDI Gating Mechanism
Sign Up to like & getrecommendations! Published in 2022 at "IEEE Journal of Biomedical and Health Informatics"
DOI: 10.1109/jbhi.2022.3153342
Abstract: Drug recommendation task based on the deep learning model has been widely studied and applied in the health care field in recent years. However, the accuracy of drug recommendation models still needs to be improved.… read more here.
Keywords: recommendation model; recommendation; drug recommendation; ddi ... See more keywords
DGANDDI: Double Generative Adversarial Networks for Drug-Drug Interaction Prediction.
Sign Up to like & getrecommendations! Published in 2022 at "IEEE/ACM transactions on computational biology and bioinformatics"
DOI: 10.1109/tcbb.2022.3219883
Abstract: Co-administration of multiple drugs may cause adverse drug interactions and side effects that damage the body. Therefore, accurate prediction of drug-drug interaction (DDI) events is of great importance. Recently, many computational methods have been proposed… read more here.
Keywords: drug drug; ddi; prediction; drug interaction ... See more keywords