Use of the French healthcare insurance database to estimate the prevalence of exposure to potential drug-drug interactions
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DOI: 10.1007/s00228-020-02952-7
Abstract: Purpose Drug-drug interactions (DDIs) require monitoring in an aging population with increasing polypharmacy exposure. We aimed to estimate the prevalence of exposure to potential DDIs using the French healthcare insurance system database, for six DDIs… read more here.
Keywords: ddis; prevalence exposure; exposure; drug ... See more keywords
Prevalence and Significance of Potential Pharmacokinetic Drug–Drug Interactions Among Patients with Lung Cancer: Implications for Clinical Trials
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DOI: 10.1007/s40261-020-00994-4
Abstract: Background The overall prevalence of potential drug–drug interactions (DDIs) among patients with lung cancer is unknown. Objective The objective of this study was to determine the prevalence of potential DDIs and major DDIs among individuals… read more here.
Keywords: ddis; patients lung; prevalence; drug ... See more keywords
Positive-Unlabeled Learning for inferring drug interactions based on heterogeneous attributes
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DOI: 10.1186/s12859-017-1546-7
Abstract: BackgroundInvestigating and understanding drug-drug interactions (DDIs) is important in improving the effectiveness of clinical care. DDIs can occur when two or more drugs are administered together. Experimentally based DDI detection methods require a large cost… read more here.
Keywords: ddis; drug interactions; drug pairs; positive unlabeled ... See more keywords
DDI-PULearn: a positive-unlabeled learning method for large-scale prediction of drug-drug interactions
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DOI: 10.1186/s12859-019-3214-6
Abstract: Drug-drug interactions (DDIs) are a major concern in patients’ medication. It’s unfeasible to identify all potential DDIs using experimental methods which are time-consuming and expensive. Computational methods provide an effective strategy, however, facing challenges due… read more here.
Keywords: ddis; method; drug; ddi pulearn ... See more keywords
Potential Drug-Drug and Herb-Drug Interactions in Patients With Cancer: A Prospective Study of Medication Surveillance.
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DOI: 10.1200/jop.2017.020859
Abstract: PURPOSE Patients with cancer frequently use herbal supplements and concomitant medications along with antineoplastic agents. These patients are at high risk of herb-drug interactions (HDIs) and drug-drug interactions (DDIs). We aimed to determine clinically relevant… read more here.
Keywords: ddis; drug interactions; patients cancer; study ... See more keywords
Predicting potential drug-drug interactions on topological and semantic similarity features using statistical learning
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DOI: 10.1371/journal.pone.0196865
Abstract: Drug-drug interaction (DDI) is a change in the effect of a drug when patient takes another drug. Characterizing DDIs is extremely important to avoid potential adverse drug reactions. We represent DDIs as a complex network… read more here.
Keywords: ddis; drug; link prediction; prediction ... See more keywords
Real-World Analysis of Potential Drug-Drug Interactions with Nirmatrelvir/Ritonavir Based on the Hospital Prescription Analysis (HPA) Database in 9 Cities of China
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DOI: 10.2147/idr.s536758
Abstract: Purpose To determine the real-world patterns and extent of potential drug-drug interactions (DDIs) related to nirmatrelvir/ritonavir (NMVr) in China. Patients and Methods Data on NMVr-treated patients from over 160 hospitals across 9 Chinese cities from… read more here.
Keywords: database; analysis; grade; real world ... See more keywords
Non-vitamin K Oral Anticoagulants and Anti-seizure Medications: A Retrospective Cohort Study
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DOI: 10.3389/fneur.2020.588053
Abstract: Purpose: Concerns of drug–drug interactions (DDIs) between anti-seizure medications (ASMs) and non-vitamin K oral anticoagulants (NOACs) have emerged in recent case reports and guidelines. Theoretically, the induction of hepatic cytochrome P450 3A4 (CYP3A4) enzyme and… read more here.
Keywords: vitamin oral; ddis; non vitamin; seizure medications ... See more keywords
Adverse drug reactions and correlations with drug–drug interactions: A retrospective study of reports from 2011 to 2020
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DOI: 10.3389/fphar.2022.923939
Abstract: Introduction: Adverse drug reactions (ADRs) represent a public health problem worldwide that deserves attention due to the impact on mortality, morbidity, and healthcare costs. Drug–drug interactions (DDIs) are an important contributor to ADRs. Most of… read more here.
Keywords: drug reactions; ddis; adverse drug; drug ... See more keywords
A practical assessment protocol for clinically relevant P-glycoprotein-mediated drug-drug interactions
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DOI: 10.3389/fphar.2024.1412692
Abstract: Background Drug-drug interactions (DDIs) may influence the effectiveness and safety of medication treatment, which may require additional monitoring, dose adjustment or avoidance of certain drugs. DDIs involving P-glycoprotein (P-gp) affect many drugs, but current official… read more here.
Keywords: clinically relevant; protocol; practice; ddis ... See more keywords
Patients with dementia: prevalence and type of drug–drug interactions
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DOI: 10.3389/fphar.2024.1472932
Abstract: Background Patients with Alzheimer’s disease (AD) and other dementias are more frequently exposed to polymedication, mainly due to the presence of comorbidities, are particularly vulnerable to drug-related problems, and present greater risk of adverse effects… read more here.
Keywords: drug interactions; drug drug; ddis; drug ... See more keywords