Characterizing the role of Tupaia DNA damage inducible transcript 3 (DDIT3) gene in viral infections.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental and comparative immunology"
DOI: 10.1016/j.dci.2021.104307
Abstract: DNA damage inducible transcript 3 (DDIT3, also known as CHOP) belongs to the CCAAT/enhancer-binding protein (C/EBP) family and plays an essential role in endoplasmic reticulum stress. Here, we characterized the potential role of the Chinese… read more here.
Keywords: dna damage; tree shrew; damage inducible; role ... See more keywords
Misfolding-induced chronic pancreatitis in CPA1 N256K mutant mice is unaffected by global deletion of Ddit3/Chop
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-09595-x
Abstract: Genetic mutations in pancreatic digestive enzymes may cause protein misfolding, endoplasmic reticulum (ER) stress and chronic pancreatitis. The CPA1 N256K mouse model carries the human p.N256K carboxypeptidase A1 (CPA1) mutation, a classic example of a… read more here.
Keywords: ddit3; mice; chronic pancreatitis; cpa1 n256k ... See more keywords
Xbp1s-Ddit3 promotes MCT-induced pulmonary hypertension.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical science"
DOI: 10.1042/cs20210612
Abstract: Pulmonary hypertension (PH) is a life-threatening disease characterized by vascular remodeling. Exploring new therapy target is urgent. The purpose of this study is to investigate whether and how spliced x-box binding protein 1 (xbp1s), a… read more here.
Keywords: protein; pulmonary hypertension; xbp1s; mct induced ... See more keywords
DDIT3 antagonizes innate immune response to promote bovine alphaherpesvirus 1 replication via the DDIT3-SQSTM1-STING pathway
Sign Up to like & getrecommendations! Published in 2022 at "Virulence"
DOI: 10.1080/21505594.2022.2044667
Abstract: ABSTRACT DNA damage-inducible transcript 3 (DDIT3), a transcription factor, is typically involved in virus replication control. We are the first to report that DDIT3 promotes the replication of bovine viral diarrhea virus, an RNA virus,… read more here.
Keywords: promote bovine; replication; ddit3; immune response ... See more keywords
Together JUN and DDIT3 (CHOP) control retinal ganglion cell death after axonal injury
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DOI: 10.1186/s13024-017-0214-8
Abstract: BackgroundOptic nerve injury is an important pathological component in neurodegenerative diseases such as traumatic optic neuropathies and glaucoma. The molecular signaling pathway(s) critical for retinal ganglion cell (RGC) death after axonal insult, however, is/are not… read more here.
Keywords: ddit3; jun ddit3; axonal injury; death ... See more keywords