DDIT4 promotes malignancy of head and neck squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23489
Abstract: This study investigated the cancer‐promoting effect of ferroptosis regulator DNA damage‐inducible transcript 4 (DDIT4) and its relevant mechanisms. Vital ferroptosis‐related genes were identified using bioinformatic methods on the basis of data collected from TCGA and… read more here.
Keywords: cell; cell carcinoma; head neck; squamous cell ... See more keywords
DDIT4 contributes to macrophage reprogramming
Sign Up to like & getrecommendations! Published in 2021 at "Nature Reviews Endocrinology"
DOI: 10.1038/s41574-021-00614-x
Abstract: Obesity and nonalcoholic fatty liver disease (NAFLD) can reprogramme macrophages, leading to chronic inflammation and the development of nonalcoholic steatohepatitis (NASH). A study in Cell Reports investigated the role of an mRNAdestabilizing RNA modification, Nmethyladenosine… read more here.
Keywords: ddit4; contributes macrophage; ddit4 contributes; macrophage reprogramming ... See more keywords
High expression of DNA damage-inducible transcript 4 (DDIT4) is associated with advanced pathological features in the patients with colorectal cancer
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-92720-z
Abstract: DNA damage-inducible transcript 4 (DDIT4) is induced in various cellular stress conditions. This study was conducted to investigate expression and prognostic significance of DDIT4 protein as a biomarker in the patients with colorectal cancer (CRC).… read more here.
Keywords: dna damage; damage inducible; ddit4; transcript ddit4 ... See more keywords
PML nuclear bodies contribute to the basal expression of the mTOR inhibitor DDIT4
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep45038
Abstract: The promyelocytic leukemia (PML) protein is an essential component of PML nuclear bodies (PML NBs) frequently lost in cancer. PML NBs coordinate chromosomal regions via modification of nuclear proteins that in turn may regulate genes… read more here.
Keywords: pml nuclear; ddit4; expression; mtor ... See more keywords