Resistance to DNA repair inhibitors in cancer
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13224
Abstract: The DNA damage response (DDR) represents a complex network of proteins which detect and repair DNA damage, thereby maintaining the integrity of the genome and preventing the transmission of mutations and rearranged chromosomes to daughter… read more here.
Keywords: resistance; ddr; cancer; resistance dna ... See more keywords
Histology of the distal dural ring
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DOI: 10.1002/ca.22916
Abstract: The distal dural ring (DDR) is a conserved intracranial anatomic structure marking the boundary point at which the internal carotid artery (ICA) exits the cavernous sinus (CS) and enters the subarachnoid space. Although the CS… read more here.
Keywords: dural ring; ica ddr; ddr; distal dural ... See more keywords
The DNA damage response pathway in normal hematopoiesis and malignancies
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Hematology"
DOI: 10.1007/s12185-017-2300-7
Abstract: In mammalian cells, the DNA damage response (DDR) prevents the replication and propagation of DNA errors to the next generation, thus maintaining genomic stability. At the heart of the DDR are the related signaling kinases… read more here.
Keywords: dna damage; ddr; damage response; dna ... See more keywords
Impact of DNA damage repair defects on response to radium-223 and overall survival in metastatic castration-resistant prostate cancer.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of cancer"
DOI: 10.1016/j.ejca.2020.05.001
Abstract: PURPOSE Radium-223 is a targeted alpha radiation therapy for metastatic castration-resistant prostate cancer. DNA damage repair (DDR) defective prostate cancers, specifically genetic aberrations leading to homologous recombination deficiency (HRD), accumulate irreparable DNA damage following genotoxic… read more here.
Keywords: prostate; dna damage; radium; radium 223 ... See more keywords
Memory effect in DDR zeolite powder and membrane synthesis
Sign Up to like & getrecommendations! Published in 2019 at "Microporous and Mesoporous Materials"
DOI: 10.1016/j.micromeso.2018.12.031
Abstract: Abstract In this work, syntheses of crystalline DDR powder and DDR membranes were studied with regard to memory effects happening to the repetitively used synthesis vessel. It was found that promoted nucleation and growth towards… read more here.
Keywords: synthesis; memory; membrane; powder ... See more keywords
Adsorption of CO2 on high silica MFI and DDR zeolites: Structural defects and differences between adsorbent samples
Sign Up to like & getrecommendations! Published in 2020 at "Microporous and Mesoporous Materials"
DOI: 10.1016/j.micromeso.2019.109818
Abstract: Abstract Equilibrium isotherms have been measured for adsorption of CO2 on several different samples of high silica zeolites (silicalite, the aluminum free form of ZSM-5 and DDR, the aluminum free form of ZSM-58), prepared by… read more here.
Keywords: adsorption; adsorption co2; high silica; structural defects ... See more keywords
Ubiquitin-like proteins in the DNA damage response: the next generation.
Sign Up to like & getrecommendations! Published in 2020 at "Essays in biochemistry"
DOI: 10.1042/ebc20190095
Abstract: DNA suffers constant insult from a variety of endogenous and exogenous sources. To deal with the arising lesions, cells have evolved complex and coordinated pathways, collectively termed the DNA damage response (DDR). Importantly, an improper… read more here.
Keywords: like proteins; damage; damage response; ubiquitin like ... See more keywords
DDR: efficient computational method to predict drug–target interactions using graph mining and machine learning approaches
Sign Up to like & getrecommendations! Published in 2018 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btx731
Abstract: Abstract Motivation Finding computationally drug–target interactions (DTIs) is a convenient strategy to identify new DTIs at low cost with reasonable accuracy. However, the current DTI prediction methods suffer the high false positive prediction rate. Results… read more here.
Keywords: method; graph; drug target; target interactions ... See more keywords
Genetic vulnerabilities upon inhibition of DNA damage response
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab643
Abstract: Abstract Because of essential roles of DNA damage response (DDR) in the maintenance of genomic integrity, cellular homeostasis, and tumor suppression, targeting DDR has become a promising therapeutic strategy for cancer treatment. However, the benefits… read more here.
Keywords: damage response; dna damage; ddr; inhibition ... See more keywords
APE1 assembles biomolecular condensates to promote the ATR–Chk1 DNA damage response in nucleolus
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1101/2022.08.22.504787
Abstract: Multifunctional protein APE1/APEX1/HAP1/Ref-1 (designated as APE1) plays important roles in nuclease-mediated DNA repair and redox regulation in transcription. However, it is unclear how APE1 regulates the DNA damage response (DDR) pathways and influences genome integrity… read more here.
Keywords: ape1; dna damage; atr ddr; ddr ... See more keywords
Ataxia Telangiectasia-Mutated Is Activated but Not Required for Productive Autographa californica Multiple Nucleopolyhedrovirus Infection
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.01269-22
Abstract: The DDR, while necessary for the maintenance and fidelity of the host genome, represents an important cellular response to viral infection. The prolific DNA baculoviruses activate and manipulate the invertebrate DDR by using mechanisms that… read more here.
Keywords: dna; replication; multiplication; ddr ... See more keywords