Recent advances in DDR (DNA damage response) inhibitors for cancer therapy.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2022.114109
Abstract: DDR (DNA damage response) defects in cells drive tumor formation by promoting DNA mutations, which also provides cancer-specific vulnerabilities that can be targeted by synthetic lethality-based therapies. Until now, PARP inhibitors like olaparib are the… read more here.
Keywords: cancer; therapy; damage response; ddr dna ... See more keywords
N-Methyl-N-nitrosourea Induced 3'-Glutathionylated DNA-Cleavage Products in Mammalian Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c02003
Abstract: Apurinic/apyrimidinic (AP) sites, that is, abasic sites, are among the most frequently induced DNA lesions. Spontaneous or DNA glycosylase-mediated β-elimination of the 3'-phosphoryl group can lead to strand cleavages at AP sites to yield a… read more here.
Keywords: induced glutathionylated; nitrosourea induced; dna; ddr dna ... See more keywords